Gastroesophageal Reflux Disease in Idiopathic Pulmonary Fibrosis: Viewer or Actor? To Treat or Not to Treat?

被引：51

作者：

Ruaro, Barbara ^{[1
]}

Pozzan, Riccardo ^{[1
]}

Confalonieri, Paola ^{[1
]}

Tavano, Stefano ^{[1
]}

Hughes, Michael ^{[2
]}

Cerinic, Marco Matucci ^{[3
,4
]}

Baratella, Elisa ^{[5
]}

Zanatta, Elisabetta ^{[6
]}

Lerda, Selene ^{[7
]}

Geri, Pietro ^{[1
]}

Confalonieri, Marco ^{[1
]}

Salton, Francesco ^{[1
]}

机构：

[1] Univ Trieste, Univ Hosp Cattinara, Dept Med Surg & Hlth Sci, Pulmonol Unit, I-34149 Trieste, Italy

[2] Univ Manchester & Salford Royal NHS Fdn Trust, Div Musculoskeletal & Dermatol Sci, Fac Biol Med & Hlth, Manchester M6 8HD, Lancs, England

[3] Univ Florence, Dept Expt & Clin Med, Div Rheumatol AOUC, Scleroderma Unit, I-50121 Florence, Italy

[4] IRCCS San Raffaele Hosp, Unit Immunol Rheumatol Allergy & Rare Dis UnIRAR, I-20132 Milan, Italy

[5] Univ Trieste, Cattinara Hosp, Dept Radiol, I-34149 Trieste, Italy

[6] Univ Padua, Dept Rheumatol, I-35122 Padua, Italy

[7] 24ORE Business Sch, Via Monte Rosa 91, I-20149 Milan, Italy

来源：

PHARMACEUTICALS | 2022年 / 15卷 / 08期

关键词：

idiopathic pulmonary fibrosis (IPF); gastro-oesophageal reflux disease (GERD); interstitial pneumonia; bronchoalveolar lavage fluid (BALF); interstitial lung disease (ILD); high-resolution computed tomography (HRTC); PROTON PUMP INHIBITORS; TRANSORAL INCISIONLESS FUNDOPLICATION; HELICOBACTER-PYLORI INFECTION; STAGE LUNG-DISEASE; HIATAL-HERNIA; NISSEN FUNDOPLICATION; ANTIREFLUX SURGERY; ANTACID THERAPY; SPHINCTER AUGMENTATION; COMPUTED-TOMOGRAPHY;

D O I：

10.3390/ph15081033

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Background: Idiopathic pulmonary fibrosis (IPF) is a rare and severe disease with a median survival of similar to 3 years. Several risk factors have been identified, such as age, genetic predisposition, tobacco exposure, and gastro-oesophageal reflux disease (GERD). Prevalence of GERD in IPF is high and may affect 87% of patients, of whom only half (47%) report symptoms. Objective: The aim of this study is to review current evidence regarding the correlation between GERD and IPF and to evaluate the current studies regarding treatments for GERD-IPF. Methods: A review to identify research papers documenting an association between GERD and IPF was performed. Results: We identified several studies that have confirmed the association between GERD and IPF, with an increased acid exposure, risk of gastric aspiration and bile acids levels in these patients. Few studies focused their attention on GERD treatment, showing how antiacid therapy was not able to change IPF evolution. Conclusions: This review investigating the correlation between GERD and IPF has confirmed the hypothesized association. However, further large prospective studies are needed to corroborate and elucidate these findings with a focus on preventative and treatment strategies.

引用

页数：15

共 104 条

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