Lipid Metabolism, Disorders and Therapeutic Drugs-Review

被引:83
作者
Natesan, Vijayakumar [1 ]
Kim, Sung-Jin [2 ]
机构
[1] Annamalai Univ, Dept Biochem & Biotechnol, Fac Sci, Annamalainagar 608002, Tamil Nadu, India
[2] Kyung Hee Univ, Sch Dent, Dept Pharmacol & Toxicol, Metab Dis Res Lab, Seoul 02447, South Korea
关键词
Lipid metabolism; Disorders; Diabetes; Cardiovascular disorder; Drugs; POLYUNSATURATED FATTY-ACIDS; CARDIOVASCULAR-DISEASE; MONOCLONAL-ANTIBODY; GUT MICROBIOTA; ETIOLOGY; OBESITY; RISK; CLASSIFICATION; CHOLESTEROL; ASSOCIATION;
D O I
10.4062/biomolther.2021.122
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Different lifestyles have an impact on useful metabolic functions, causing disorders. Different lipids are involved in the metabolic functions that play various vital roles in the body, such as structural components, storage of energy, in signaling, as biomarkers, in energy metabolism, and as hormones. Inter-related disorders are caused when these functions are affected, like diabetes, cancer, infections, and inflammatory and neurodegenerative conditions in humans. During the Covid-19 period, there has been a lot of focus on the effects of metabolic disorders all over the world. Hence, this review collectively reports on research concerning metabolic disorders, mainly cardiovascular and diabetes mellitus. In addition, drug research in lipid metabolism disorders have also been considered. This review explores lipids, metabolism, lipid metabolism disorders, and drugs used for these disorders.
引用
收藏
页码:596 / 604
页数:9
相关论文
共 90 条
[1]  
Ahmed S., 2021, BIOCH LIPIDS, P11
[2]   Triglyceride Metabolism in the Liver [J].
Alves-Bezerra, Michele ;
Cohen, David E. .
COMPREHENSIVE PHYSIOLOGY, 2018, 8 (01) :1-22
[3]   Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2+ Breast Cancer [J].
Alwarawrah, Yazan ;
Hughes, Philip ;
Loiselle, David ;
Carlson, David A. ;
Darr, David B. ;
Jordan, Jamie L. ;
Xiong, Jessie ;
Hunter, Lucas M. ;
Dubois, Laura G. ;
Thompson, J. Will ;
Kulkarni, Manjusha M. ;
Ratcliff, Annette N. ;
Kwiek, Jesse J. ;
Haystead, Timothy A. J. .
CELL CHEMICAL BIOLOGY, 2016, 23 (06) :678-688
[4]  
Amalan V., 2015, Indian J. Appl. Res., V5, P10
[5]  
Amalan V., 2015, J. Chem. Pharm. Res, V7, P831
[6]   Obesity, fatty liver disease and intestinal microbiota [J].
Arslan, Nur .
WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (44) :16452-16463
[7]   Urea cycle pathway targeted therapeutic action of naringin against ammonium chloride induced hyperammonemic rats [J].
Arumugam, Ramakrishnan ;
Natesan, Vijayakumar .
BIOMEDICINE & PHARMACOTHERAPY, 2017, 94 :1028-1037
[8]   The life cycle of neutral lipids: synthesis, storage and degradation [J].
Athenstaedt, K. ;
Daum, G. .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2006, 63 (12) :1355-1369
[9]  
Azhar S, 2010, FUTUR CARDIOL, V6, P657, DOI [10.2217/fca.10.86, 10.2217/FCA.10.86]
[10]   Radiographic measure of aorta calcification is a site-specific predictor of bone loss and fracture risk at the hip [J].
Bagger, Y. Z. ;
Tanko, L. B. ;
Alexandersen, P. ;
Qin, G. ;
Christiansen, C. .
JOURNAL OF INTERNAL MEDICINE, 2006, 259 (06) :598-605