Total Synthesis of (±)-Hippolachnin A

被引：84
作者：
Ruider, Stefan A. [1 ]
Sandmeier, Tobias [1 ]
Carreira, Erick M. [1 ]
机构：
[1] ETH, Lab Organ Chem, CH-8093 Zurich, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 08期
关键词：
ene reaction; hippolachninA; natural products; photochemistry; total synthesis; CATALYZED HYDROHYDRAZINATION; MOLECULAR-OXYGEN; BCDE-RING; OLEFINS; ALKENES; HYDROAZIDATION; CYCLOADDITION; PHENYLSILANE; ACCESS; METAL;
D O I：
10.1002/anie.201410419
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The first total synthesis of the marine polyketide (+/-)-hippolachninA has been achieved in nine linear steps and an overall yield of 9%. Rapid access to the oxacyclobutapentalene core structure was secured by strategic application of an ene cyclization.
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收藏
页码：2378 / 2382
页数：5
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