Activation of "silent" vasoconstrictive 5-HT1A receptors as a possible mechanism of synergism in angiotensin II and serotonin effect on vascular tone

被引：4

作者：

Kozhevnikova, L. M. ^{[1
]}

Sukhanova, I. F. ^{[2
]}

Avdonin, P. V. ^{[1
,2
]}

机构：

[1] Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia

[2] Russian Acad Sci, Koltzov Inst Dev Biolm, Moscow 119991, Russia

来源：

BIOLOGY BULLETIN | 2011年 / 38卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

SPONTANEOUSLY HYPERTENSIVE RAT; MESENTERIC-ARTERIES; INDUCED CONTRACTION; BLOOD-PRESSURE; KETANSERIN; ENDOTHELIN-1; ANTAGONISM; RITANSERIN; 5-HYDROXYTRYPTAMINE; POTENTIATION;

D O I：

10.1134/S1062359011010079

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It has been shown that the agonist of 5HT1A-receptors 8-OH-DPAT induces contraction of aortic rings in the presence of angiotensin II. This effect is not associated with activation of alpha(1)-adrenoceptors by 8-OH-DPAT as it is reproduced in the presence of prazosin which completely suppresses the nonspecific vasoconstrictive effect of 8-OH-DPAT via alpha(1)-adrenoceptors on the aorta incubated without angiotensin II. Synergism in the action of angiotensin II and 8-OH-DPAT is completely preserved after partial desensitization of the receptors of angiotensin II. It has been found that 8-OH-DPAT increases the free cytoplasmic calcium concentration in cultured smooth muscle cells from the rat aorta. The data obtained support the hypothesis about the existence of "silent" vasoconstrictive 5HT1A-receptors. It has been suggested that activation of these receptors underlies synergism in vasoconstrictive action of serotonin and angiotensin II.

引用

页码：57 / 64

页数：8

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