The Cross Talk between Underlying Mechanisms of Multiple Sclerosis and Epilepsy May Provide New Insights for More Efficient Therapies

被引：14

作者：

Rayatpour, Atefeh ^{[1
,2
]}

Farhangi, Sahar ^{[1
,2
]}

Verdaguer, Ester ^{[3
,4
,5
]}

Olloquequi, Jordi ^{[6
]}

Urena, Jesus ^{[3
,4
,5
]}

Auladell, Carme ^{[3
,4
,5
]}

Javan, Mohammad ^{[1
,2
,7
]}

机构：

[1] Tarbiat Modares Univ, Fac Med Sci, Dept Physiol, Tehran 1411713116, Iran

[2] Tarbiat Modares Univ, Inst Brain & Cognit, Tehran 1411713116, Iran

[3] Univ Barcelona, Physiol & Immunol Biol Fac, Dept Cell Biol, Barcelona 08028, Spain

[4] Inst Salud Carlos III, Ctr Biomed Res Neurodegenerat Dis CIBERNED, Madrid 28029, Spain

[5] Univ Barcelona, Inst Neurosci, Barcelona 08035, Spain

[6] Univ Autonoma Chile, Fac Hlth Sci, Lab Cellular & Mol Pathol, Biomed Sci Inst, Talca 3460000, Chile

[7] ACECR, Royan Inst Stem Cell Biol & Technol, Cell Sci Res Ctr, Dept Brain & Cognit Sci, Tehran 1411713116, Iran

来源：

PHARMACEUTICALS | 2021年 / 14卷 / 10期

基金：

芬兰科学院;

关键词：

multiple sclerosis; demyelination; epilepsy; seizure; neurodegeneration; TEMPORAL-LOBE EPILEPSY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; WHITE-MATTER ABNORMALITIES; CORPUS-CALLOSUM; MITOCHONDRIAL DYSFUNCTION; OLIGODENDROCYTE SURVIVAL; INDUCED DEMYELINATION; HIPPOCAMPAL MYELIN; SEIZURES; RAT;

D O I：

10.3390/ph14101031

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Despite the significant differences in pathological background of neurodegenerative diseases, epileptic seizures are a comorbidity in many disorders such as Huntington disease (HD), Alzheimer's disease (AD), and multiple sclerosis (MS). Regarding the last one, specifically, it has been shown that the risk of developing epilepsy is three to six times higher in patients with MS compared to the general population. In this context, understanding the pathological processes underlying this connection will allow for the targeting of the common and shared pathological pathways involved in both conditions, which may provide a new avenue in the management of neurological disorders. This review provides an outlook of what is known so far about the bidirectional association between epilepsy and MS.</p>

引用

页数：23

共 201 条

[1] Movement disorders in early MS and related diseases A prospective observational study [J].