A Method for Synthesis of 3-Hydroxy-1-indanones via Cu-Catalyzed Intramolecular Annulation Reactions

被引：33

作者：

He, Guoxue ^{[1
]}

Wu, Chenglin ^{[2
,3
]}

Zhou, Jianhui ^{[2
,3
]}

Yang, Qaolan ^{[2
,3
]}

Zhang, Chunmei ^{[2
,3
]}

Zhou, Yu ^{[2
,3
]}

Zhang, Huabei ^{[1
]}

Liu, Hong ^{[2
,3
]}

机构：

[1] Beijing Normal Univ, Coll Chem, Key Lab Radiopharmaceut, Minist Educ, 19 Xinjiekouwai St, Beijing 100875, Peoples R China

[2] Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China

[3] Chinese Acad Sci, Key Lab Receptor Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 21期

基金：

中国国家自然科学基金;

关键词：

INDANONE DERIVATIVES; COLEOPHOMONE-B; PTEROSIN-C; ALKYNES; INHIBITORS; TANDEM; HYDRATION;

D O I：

10.1021/acs.joc.8b02149

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a facile and highly efficient method that copper-catalyzed intramolecular annulation to synthesize 3-hydroxy-1-indanones employing simple 2-ethynylbenzaldehyde as starting materials was achieved successfully. This protocol provided a simple synthetic approach to afford 3-hydroxy-1-indanones under mild conditions in good to excellent yields.

引用

收藏

页码：13356 / 13362

页数：7

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