Human surrogate models of neuropathic pain: validity and limitations

被引：10

作者：

Binder, Andreas ^{[1
]}

机构：

[1] Univ Hosp Schleswig Holstein, Dept Neurol, Div Neurol Pain Res & Therapy, Campus Kiel,Arnold Heller Str 3,Haus 41, D-24105 Kiel, Germany

来源：

PAIN | 2016年 / 157卷 / 02期

关键词：

Capsaicin; Menthol; Human pain model; Neuropathic pain; TOPICAL CAPSAICIN INDUCE; SENSITIZATION; MENTHOL; MECHANISMS; COLD; REPRODUCIBILITY; HYPERALGESIA; NOCICEPTORS; PHENOTYPE; ANALGESIA;

D O I：

10.1097/j.pain.0000000000000460

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Human surrogate models of neuropathic pain in healthy subjects are used to study symptoms, signs, and the hypothesized underlying mechanisms. Although different models are available, different spontaneous and evoked symptoms and signs are inducible; 2 key questions need to be answered: are human surrogate models conceptually valid, ie, do they share the sensory phenotype of neuropathic pain states, and are they sufficiently reliable to allow consistent translational research?

引用

页码：S48 / S52

页数：5

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