Direct Copper-Catalyzed C-H Monofluoroalkylation of Benzoxazoles with 1-Fluoro-1-haloalkanes

被引：11
作者：
Li, Wei [1 ]
Varenikov, Andrii [1 ]
Gandelman, Mark [1 ]
机构：
[1] Technion Israel Inst Technol, Schulich Fac Chem, IL-3200008 Haifa, Israel
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 21期
关键词：
C-H activation; Secondary alkyl fluorides; Cross-coupling; Copper; Benzoxazoles; ARYLBORONIC ACIDS; FACILE ACCESS; FLUORINE; TRIFLUOROMETHYLATION; MONOFLUOROMETHYLATION; FLUOROALKYLATION; ARYLATION;
D O I：
10.1002/ejoc.201901929
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first example of direct C-H bond monofluoroalkylation with 1-fluoro-1-haloalkanes with no adjacent functional groups and with beta-hydrogens has been developed. This transformation offers a straightforward route for the synthesis of a series of monofluoroalkylated benzoxazoles.
引用
收藏
页码：3138 / 3141
页数：4
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