PGD2, IL-1-FAMILY MEMBERS AND MAST CELLS

被引：15

作者：

Anogeianaki, A. ^{[1
]}

Castellani, M. L. ^{[2
]}

Tripodi, D. ^{[3
]}

Felaco, P. ^{[4
]}

Toniato, E. ^{[2
]}

De Lutiis, M. A. ^{[4
]}

Fulcheri, M. ^{[5
]}

Tete, S. ^{[3
]}

Galzio, R. ^{[6
]}

Salini, V. ^{[7
]}

Caraffa, A. ^{[8
]}

Antinolfi, P. ^{[8
]}

Frydas, I. ^{[9
]}

Sabatino, G. ^{[10
]}

Shaik-Dasthagirisaheb, Y. B. ^{[11
]}

机构：

[1] Aristotle Univ Thessaloniki, Sch Med, Dept Physiol, Thessaloniki, Greece

[2] Univ G dAnnunzio, Div Immunol, Chieti, Italy

[3] Univ G dAnnunzio, Sch Dent, Chieti, Italy

[4] Univ G dAnnunzio, Dept Human Dynam, Chieti, Italy

[5] Univ G dAnnunzio, Dept Clin Psychol, Chieti, Italy

[6] Univ Aquila, Dept Hlth Sci, I-67100 Laquila, Italy

[7] Univ G dAnnunzio, Orthopaed Div, Chieti, Italy

[8] Univ Perugia, Orthopaed Div, I-06100 Perugia, Italy

[9] Aristotle Univ Thessaloniki, Sch Vet Med, Lab Parasitol & Parasit Dis, GR-54006 Thessaloniki, Greece

[10] Univ G dAnnunzio, Dept Internal Med & Ageing, Chieti, Italy

[11] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA

来源：

EUROPEAN JOURNAL OF INFLAMMATION | 2010年 / 8卷 / 03期

关键词：

cytokines; prostaglandins; IL-1; inflammation; CORTICOTROPIN-RELEASING HORMONE; BLOOD-BRAIN-BARRIER; VASCULAR-PERMEABILITY; GROWTH-FACTOR; TNF-ALPHA; T-CELL; ACTIVATION; IGE; DEGRANULATION; EXPRESSION;

D O I：

10.1177/1721727X1000800301

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytokines are immunomodulatory and inflammatory compounds produced by many different Cell types The IL-1 family consists of at least eleven cytokines. including IL-18 and IL-13 and are essential to the host defence against severe infections and mediate inflammation IL-18 also enhances tumour rejection and has high capacity to augment the cytotoxicity of NK cells and T cells IL-33 stimulates basophils and mast cells to produce cytokines and histamine independently of IgE Mast cells play a crucial role in the development of allergy through the cross-linking of their surface receptors for IgE leading to degranulation and inflammation Activated mast cells induce the generation of PGD2, detectable in 2-15 minutes after challenge, and LTC4 Here we review the interrelationship between PGD2, IL-1 family members and mast cells

引用

页码：137 / 142

页数：6

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