Treatment-refractory autoimmune sensorineural hearing loss: Response to infliximab

被引：16

作者：

Liu, Yi-Chun ^{[2
]}

Rubin, Rene ^{[3
]}

Sataloff, Robert T. ^{[1
]}

机构：

[1] Drexel Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA 19103 USA

[2] Case Western Reserve Univ, Dept Otolaryngol Head & Neck Surg, Cleveland, OH 44106 USA

[3] Drexel Univ, Coll Med, Dept Med, Philadelphia, PA 19103 USA

来源：

ENT-EAR NOSE & THROAT JOURNAL | 2011年 / 90卷 / 01期

关键词：

INNER-EAR; AUTOANTIBODIES; ANTIBODY; METHOTREXATE; ETANERCEPT; THERAPY; DISEASE;

D O I：

10.1177/014556131109000107

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

We conducted a retrospective study to assess the effects of infliximab, a chimeric monoclonal antibody, on hearing in patients with autoimmune sensorineural hearing loss who had previously not responded to steroid therapy and/or treatment with other immunosuppressive drugs such as methotrexate and cyclophosphamide. We reviewed the records of 8 such patients. Our objective measures of outcome were pure-tone averages at 500, 1,000, 2,000, and 3,000 Hz and speech discrimination scores. At the completion of treatment, no patient exhibited a positive response to infliximab therapy by objective measurements, and only 1 patient (12.5%) reported subjective improvement.

引用

页码：23 / 28

页数：6

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