The MYC Enhancer-ome: Long-Range Transcriptional Regulation of MYC in Cancer

被引：104

作者：

Lancho, Olga ^{[1
]}

Herranz, Daniel ^{[1
,2
]}

机构：

[1] Rutgers State Univ, Rutgers Canc Inst New Jersey, New Brunswick, NJ 08901 USA

[2] Rutgers State Univ, Robert Wood Johnson Med Sch, Dept Pharmacol, Piscataway, NJ 08854 USA

来源：

TRENDS IN CANCER | 2018年 / 4卷 / 12期

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; PROSTATE-CANCER; SUPER-ENHANCERS; C-MYC; SUSCEPTIBILITY LOCI; GENE-EXPRESSION; SNP RS6983267; RISK; VARIANT; ONCOGENE;

D O I：

10.1016/j.trecan.2018.10.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MYC is one of the most important oncogenes in cancer. Indeed, MYC is upregulated in 50-60% of all tumors. MYC overexpression can be achieved through a variety of mechanisms, including gene duplications, chromosomal translocations, or somatic mutations leading to increased MYC stability. However, recent studies have identified numerous tissue-specific noncoding enhancers of MYC that play major roles in cancer, highlighting long-range transcriptional regulation of MYC as a critical novel mechanism leading to MYC hyperactivation and as a potential target for new therapeutic strategies in the near future. Here we summarize the regions and mechanisms involved in the long-range transcriptional regulation of MYC, underscoring the relevance of MYC enhancers both in normal physiological development and in MYC-driven cancer initiation and progression.

引用

页码：810 / 822

页数：13

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