Myocardial T1 Mapping - Hope or Hype?

被引：70

作者：

Bulluck, Heerajnarain ^{[1
,2
,3
,4
]}

Maestrini, Viviana ^{[1
,2
,6
]}

Rosmini, Stefania ^{[1
,2
]}

Abdel-Gadir, Amna ^{[1
,2
,3
]}

Treibel, Thomas A. ^{[1
,2
,3
]}

Castelletti, Silvia ^{[1
,2
]}

Bucciarelli-Ducci, Chiara ^{[5
]}

Manisty, Charlotte ^{[1
,2
,3
]}

Moon, James C. ^{[1
,2
,3
]}

机构：

[1] Heart Hosp Imaging Ctr, London W1G 8PH, England

[2] Barts Heart Ctr, London, England

[3] UCL, Inst Cardiovasc Sci, London, England

[4] UCL, Hatter Cardiovasc Inst, London, England

[5] Univ Bristol, Bristol NIHR Cardiovasc BRU, Bristol Heart Inst, Dept Cardiol, Bristol, Avon, England

[6] Univ Roma La Sapienza, Dept Cardiovasc Resp Nephrol Anesthesiol & Geriat, I-00185 Rome, Italy

来源：

CIRCULATION JOURNAL | 2015年 / 79卷 / 03期

关键词：

Biomarkers; Cardiovascular MRI; Diffuse fibrosis; Imaging; T1; mapping; CARDIOVASCULAR MAGNETIC-RESONANCE; EXTRACELLULAR VOLUME FRACTION; LATE GADOLINIUM ENHANCEMENT; VALVULAR HEART-DISEASE; DIFFUSE VENTRICULAR FIBROSIS; INVERSION-RECOVERY MOLLI; ANDERSON-FABRY DISEASE; TASK-FORCE; HISTOLOGICAL VALIDATION; T1-MAPPING DETECTS;

D O I：

10.1253/circj.CJ-15-0054

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiovascular magnetic resonance is a well-established tool for the quantification of focal fibrosis. With the introduction of T1 mapping, diffuse myocardial processes can be detected and quantified. In particular, infiltration and storage disorders with large disease-related changes, and diffuse fibrosis where measurement is harder but the potential impact larger. This has added a new dimension to the understanding and assessment of various myocardial diseases. T1 mapping promises to detect early disease, quantify disease severity and provide prognostic insights into certain conditions. It also has the potential to be a robust surrogate marker in drug development trials to monitor therapeutic response and be a prognostic marker in certain diseases. T1 mapping is an evolving field and numerous factors currently preclude its standardization. In this review, we describe the current status of T1 mapping and its potential promises and pitfalls.

引用

页码：487 / 494

页数：8

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