Biopsy-based single-cell transcriptomics reveals MAIT cells as potential targets for controlling fibrosis-related liver inflammation due to chronic hepatitis-B infection

被引：4
作者：
Shao, Li [1 ]
Zhao, Hong [3 ]
Guo, Rongfang [2 ]
Cheng, Jinlin [3 ]
Lu, Xiaoyan [2 ]
Fan, Xiaohui [2 ,4 ,5 ]
机构：
[1] Hangzhou Normal Univ, Affiliated Hosp Hangzhou Normal Univ, Sch Clin Med, Hangzhou, Peoples R China
[2] Zhejiang Univ, Pharmaceut Informat Inst, Coll Pharmaceut Sci, Hangzhou, Peoples R China
[3] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Hangzhou, Peoples R China
[4] Zhejiang Univ, State Key Lab Component Based Chinese Med, Innovat Ctr, Hangzhou, Peoples R China
[5] Westlake Lab Life Sci & Biomed, Hangzhou, Peoples R China
来源：
CLINICAL AND TRANSLATIONAL MEDICINE | 2022年 / 12卷 / 10期
基金：
中国国家自然科学基金;
关键词：
IMMUNE-RESPONSES;
D O I：
10.1002/ctm2.1073
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页数：7
相关论文
共 10 条
[1]   Toll-Like Receptor 8 Agonist and Bacteria Trigger Potent Activation of Innate Immune Cells in Human Liver [J].
Jo, Juandy ;
Tan, Anthony T. ;
Ussher, James E. ;
Sandalova, Elena ;
Tang, Xin-Zi ;
Tan-Garcia, Alfonso ;
To, Natalie ;
Hong, Michelle ;
Chia, Adeline ;
Gill, Upkar S. ;
Kennedy, Patrick T. ;
Tan, Kai Chah ;
Lee, Kang Hoe ;
De Libero, Gennaro ;
Gehring, Adam J. ;
Willberg, Christian B. ;
Klenerman, Paul ;
Bertoletti, Antonio .
PLOS PATHOGENS, 2014, 10 (06)
[2]   Macrophage Phenotypes and Hepatitis B Virus Infection [J].
Li, Yujia ;
Li, Shilin ;
Duan, Xiaoqiong ;
Yang, Chunhui ;
Xu, Min ;
Chen, Limin .
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2020, 8 (04) :424-431
[3]   MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection [J].
Meierovics, Anda ;
Yankelevich, Wei-Jen Chua ;
Cowley, Siobhan C. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (33) :E3119-E3128
[4]   Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury [J].
Pyzik, Michal ;
Rath, Timo ;
Kuo, Timothy T. ;
Win, Sanda ;
Baker, Kristi ;
Hubbard, Jonathan J. ;
Grenha, Rosa ;
Gandhi, Amit ;
Kraemer, Thomas D. ;
Mezo, Adam R. ;
Taylor, Zachary S. ;
McDonnell, Kevin ;
Nienaber, Vicki ;
Andersen, Jan Terje ;
Mizoguchi, Atsushi ;
Blumberg, Laurence ;
Purohit, Shalaka ;
Jones, Susan D. ;
Christianson, Greg ;
Lencer, Wayne I. ;
Sandlie, Inger ;
Kaplowitz, Neil ;
Roopenian, Derry C. ;
Blumberg, Richard S. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (14) :E2862-E2871
[5]   Molecular biology of hepatitis B virus infection [J].
Seeger, Christoph ;
Mason, William S. .
VIROLOGY, 2015, 479 :672-686
[6]   MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression [J].
Shaler, Christopher R. ;
Choi, Joshua ;
Rudak, Patrick T. ;
Memarnejadian, Arash ;
Szabo, Peter A. ;
Tun-Abraham, Mauro E. ;
Rossjohn, Jamie ;
Corbett, Alexandra J. ;
McCluskey, James ;
McCormick, John K. ;
Lantz, Olivier ;
Hernandez-Alejandro, Roberto ;
Haeryfar, S. M. Mansour .
PLOS BIOLOGY, 2017, 15 (06)
[7]   Circulating Th17 cells frequency is associated with the disease progression in HBV infected patients [J].
Wu, Wei ;
Li, Jie ;
Chen, Feng ;
Zhu, Haihong ;
Peng, Guoping ;
Chen, Zhi .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2010, 25 (04) :750-757
[8]   Single-cell RNA sequencing reveals intrahepatic and peripheral immune characteristics related to disease phases in HBV-infected patients [J].
Zhang, Chao ;
Li, Jiesheng ;
Cheng, Yongqian ;
Meng, Fanping ;
Song, Jin-Wen ;
Fan, Xing ;
Fan, Hongtao ;
Li, Jing ;
Fu, Yu-Long ;
Zhou, Ming-Ju ;
Hu, Wei ;
Wang, Si-Yu ;
Fu, Yuan-Jie ;
Zhang, Ji-Yuan ;
Xu, Ruo-Nan ;
Shi, Ming ;
Hu, Xueda ;
Zhang, Zemin ;
Ren, Xianwen ;
Wang, Fu-Sheng .
GUT, 2023, 72 (01) :153-167
[9]   Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection [J].
Zhang, Ejuan ;
Lu, Mengji .
MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 2015, 204 (01) :11-20
[10]   NK Cells Help Induce Anti-Hepatitis B Virus CD8+ T Cell Immunity in Mice [J].
Zheng, Meijuan ;
Sun, Rui ;
Wei, Haiming ;
Tian, Zhigang .
JOURNAL OF IMMUNOLOGY, 2016, 196 (10) :4122-4131
1