Antibody dynamics after tick-borne encephalitis and measles-mumps-rubella vaccination in children post early thymectomy

被引：16
作者：
Zlamy, Manuela [1 ]
Wuerzner, Reinhard [2 ]
Holzmann, Heidemarie [3 ]
Brandstaetter, Anita [4 ]
Jeller, Verena [1 ]
Zimmerhackl, Lothar Bernd [1 ]
Prelog, Martina [1 ,5 ]
机构：
[1] Med Univ Innsbruck, Dept Pediat, A-6020 Innsbruck, Austria
[2] Med Univ Innsbruck, Div Hyg & Microbiol, A-6020 Innsbruck, Austria
[3] Med Univ Vienna, Clin Inst Virol, Vienna, Austria
[4] Med Univ Innsbruck, Sect Genet Epidemiol, A-6020 Innsbruck, Austria
[5] Univ Wurzburg, Univ Childrens Hosp, D-97070 Wurzburg, Germany
来源：
VACCINE | 2010年 / 28卷 / 51期
关键词：
Thymectomy; Tick-borne encephalitis vaccination; Aging; Avidity; Antibodies; T-CELL COMPARTMENT; CYTOMEGALOVIRUS-INFECTION; NEONATAL THYMECTOMY; BOOSTER VACCINATION; IMMUNE-RESPONSES; IMMUNOSENESCENCE; PERSISTENCE; SAFETY; ADULTS; VIRUS;
D O I：
10.1016/j.vaccine.2010.10.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Thymectomized patients (TP) showed a delayed humoral immune response to tick-borne-encephalitis-virus (TBEV) vaccination, which served as a neo-antigen. From the previously published cohort, the TBEV-specific IgG concentrations and avidities were analyzed in 17 TP compared to 30 non-thymectomized healthy controls (HC) 220 weeks after the first TBE vaccination to identify patients with waning antibodies. Only in HC, increase of avidity was significant between 8 and 220 weeks (p < 0.001), whereas TP showed a lower avidity maturation at week 48(p < 0.05). Cytomegalovirus (CMV) seropositivity at vaccination did not influence the humoral immune response. The ability of TP to maintain measles, mumps and rubella (MMR)-specific antibodies at least 8 years post (MMR) vaccination was evaluated in the serum samples of TP, retrospectively. Although all TP had MMR vaccination at least 6 months after thymectomy, TP showed no significant difference regarding MMR-specific IgG concentrations or avidities compared to HC. Regarding TBE vaccination, the data confirmed the previous observation of a delayed primary immune response in TP to TBE vaccine and also revealed an altered memory priming by paucity of high-avidity antibodies. (c) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8053 / 8060
页数：8
相关论文
共 56 条
[41]   Antibody persistence following booster vaccination against tick-borne encephalitis: 3-year post-booster follow-up [J].
Rendi-Wagner, Pamela ;
Paulke-Korinek, Maria ;
Kundi, Michael ;
Wiedermann, Ursula ;
Laaber, Brigitte ;
Kollaritsch, Herwig .
VACCINE, 2007, 25 (27) :5097-5101
[42]   Persistence of antibodies after vaccination against tick-borne encephalitis [J].
Rendi-Wagner, Pamela ;
Zent, Olaf ;
Jilg, Wolfgang ;
Plentz, Annelie ;
Beran, Jiri ;
Kollaritsch, Herwig .
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2006, 296 :202-207
[43]   Characterization of CD4+T-cell-dendritic cell interactions during secondary antigen exposure in tolerance and priming [J].
Rush, Catherine M. ;
Millington, Owain R. ;
Hutchison, Sharon ;
Bryson, Karen ;
Brewer, James M. ;
Garside, Paul .
IMMUNOLOGY, 2009, 128 (04) :463-471
[44]   Evidence of premature immune aging in patients thymectomized during early childhood [J].
Sauce, Delphine ;
Larsen, Martin ;
Fastenackels, Solene ;
Duperrier, Anne ;
Keller, Michael ;
Grubeck-Loebenstein, Beatrix ;
Ferrand, Christophe ;
Debre, Patrice ;
Sidi, Daniel ;
Appay, Victor .
JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (10) :3070-3078
[45]   Lack of antibody production following immunization in old age:: Association with CD8+CD28- T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines [J].
Saurwein-Teissl, M ;
Lung, TL ;
Marx, F ;
Gschösser, C ;
Asch, E ;
Blasko, I ;
Parson, W ;
Böck, G ;
Schönitzer, D ;
Trannoy, E ;
Grubeck-Loebenstein, B .
JOURNAL OF IMMUNOLOGY, 2002, 168 (11) :5893-5899
[46]   Age-related appearance of a CMV-specific high-avidity CD8+ T cell clonotype which does not occur in young adults [J].
Schwanninger A. ;
Weinberger B. ;
Grubeck-Loebenstein B. ;
Weiskopf D. ;
Herndler-Brandstetter D. ;
Reitinger S. ;
Gassner C. ;
Schennach H. ;
Parson W. ;
Würzner R. .
Immunity & Ageing, 5 (1)
[47]   Evidence for extrathymic T cell maturation after thymectomy in infancy [J].
Torfadottir, H. ;
Freysdottir, J. ;
Skaftadottir, I. ;
Haraldsson, A. ;
Sigfusson, G. ;
Ogmundsdottir, H. M. .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2006, 145 (03) :407-412
[48]   Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination - an impact of immunosenescence [J].
Trzonkowski, P ;
Mysliwska, J ;
Szmit, E ;
Wieckiewicz, J ;
Lukaszuk, K ;
Brydak, LB ;
Machala, M ;
Mysliwski, A .
VACCINE, 2003, 21 (25-26) :3826-3836
[49]   Persistent and selective deficiency of CD4+ T cell immunity to cytomegalovirus in immunocompetent young children [J].
Tu, WW ;
Chen, S ;
Sharp, M ;
Dekker, C ;
Manganello, AM ;
Tongson, EC ;
Maecker, HT ;
Holmes, TH ;
Wang, ZT ;
Kemble, G ;
Adler, S ;
Arvin, A ;
Lewis, DB .
JOURNAL OF IMMUNOLOGY, 2004, 172 (05) :3260-3267
[50]   The developing human immune system: T-cell receptor repertoire of children and young adults shows a wide discrepancy in the frequency of persistent oligoclonal T-cell expansions [J].
Wedderburn, LR ;
Patel, A ;
Varsani, H ;
Woo, P .
IMMUNOLOGY, 2001, 102 (03) :301-309
123456