Antibody dynamics after tick-borne encephalitis and measles-mumps-rubella vaccination in children post early thymectomy

被引：16

作者：

Zlamy, Manuela ^{[1
]}

Wuerzner, Reinhard ^{[2
]}

Holzmann, Heidemarie ^{[3
]}

Brandstaetter, Anita ^{[4
]}

Jeller, Verena ^{[1
]}

Zimmerhackl, Lothar Bernd ^{[1
]}

Prelog, Martina ^{[1
,5
]}

机构：

[1] Med Univ Innsbruck, Dept Pediat, A-6020 Innsbruck, Austria

[2] Med Univ Innsbruck, Div Hyg & Microbiol, A-6020 Innsbruck, Austria

[3] Med Univ Vienna, Clin Inst Virol, Vienna, Austria

[4] Med Univ Innsbruck, Sect Genet Epidemiol, A-6020 Innsbruck, Austria

[5] Univ Wurzburg, Univ Childrens Hosp, D-97070 Wurzburg, Germany

来源：

VACCINE | 2010年 / 28卷 / 51期

关键词：

Thymectomy; Tick-borne encephalitis vaccination; Aging; Avidity; Antibodies; T-CELL COMPARTMENT; CYTOMEGALOVIRUS-INFECTION; NEONATAL THYMECTOMY; BOOSTER VACCINATION; IMMUNE-RESPONSES; IMMUNOSENESCENCE; PERSISTENCE; SAFETY; ADULTS; VIRUS;

D O I：

10.1016/j.vaccine.2010.10.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Thymectomized patients (TP) showed a delayed humoral immune response to tick-borne-encephalitis-virus (TBEV) vaccination, which served as a neo-antigen. From the previously published cohort, the TBEV-specific IgG concentrations and avidities were analyzed in 17 TP compared to 30 non-thymectomized healthy controls (HC) 220 weeks after the first TBE vaccination to identify patients with waning antibodies. Only in HC, increase of avidity was significant between 8 and 220 weeks (p < 0.001), whereas TP showed a lower avidity maturation at week 48(p < 0.05). Cytomegalovirus (CMV) seropositivity at vaccination did not influence the humoral immune response. The ability of TP to maintain measles, mumps and rubella (MMR)-specific antibodies at least 8 years post (MMR) vaccination was evaluated in the serum samples of TP, retrospectively. Although all TP had MMR vaccination at least 6 months after thymectomy, TP showed no significant difference regarding MMR-specific IgG concentrations or avidities compared to HC. Regarding TBE vaccination, the data confirmed the previous observation of a delayed primary immune response in TP to TBE vaccine and also revealed an altered memory priming by paucity of high-avidity antibodies. (c) 2010 Elsevier Ltd. All rights reserved.

引用

页码：8053 / 8060

页数：8

共 56 条

[1] Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons [J].