Different regional brain volume loss in pure and complicated hereditary spastic paraparesis: A voxel-based morphometric study

被引：9
作者：
Kassubek, Jan
Juengling, Freimut D.
Baumgartner, Annette
Unrath, Alexander
Ludolph, Albert C.
Sperfeld, Anne-D.
机构：
[1] Univ Ulm, Dept Neurol, D-89081 Ulm, Germany
[2] Univ Bern, Dept Nucl Med, CH-3012 Bern, Switzerland
来源：
AMYOTROPHIC LATERAL SCLEROSIS | 2007年 / 8卷 / 06期
关键词：
Corpus callosum; hereditary spastic paraparesis; magnetic resonance imaging; voxel-based morphometry;
D O I：
10.1080/17482960701500718
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Three-dimensional magnetic resonance imaging of the brain was analyzed using optimized voxel-based morphometry in 21 patients with pure hereditary spastic paraparesis (pHSP) and 12 patients with complicated HSP (cHSP). PHSP patients showed only small regional grey matter volume reduction, whereas significantly decreased grey matter volumes were localized pericentrally in cHSP. In the white matter, several small areas of regional volume reduction were observed in the pHSP patients, whereas the cHSP group exhibited large robust volume reduction involving the entire corpus callosum, a result that was reproduced by an additional region-based MRI analysis. It could be demonstrated that the topography of cerebral volume changes differed markedly in pHSP or cHSP at group level. Corpus callosum thinning seems to be a general feature of cHSP.
引用
收藏
页码：328 / 336
页数：9
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