Organophosphate induced delayed polyneuropathy in man: An overview

被引：53

作者：

Jokanovic, Milan ^{[1
,2
]}

Kosanovic, Melita ^{[3
]}

Brkic, Dejan ^{[1
]}

Vukomanovic, Predrag ^{[1
]}

机构：

[1] Univ Nish, Fac Med, Nish, Serbia

[2] Acad Sci & Arts Republ Srpska, Banja Luka, Bosnia & Herceg

[3] United Arab Emirates Univ, Fac Med & Hlth Sci, Al Ain, U Arab Emirates

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 2011年 / 113卷 / 01期

关键词：

Organophosphorus; Organophosphate induced delayed polyneuropathy; Neuropathy target esterase; NEUROPATHY TARGET ESTERASE; CRESYL PHOSPHATE; NEUROTOXIC ESTERASE; PARALYSIS; PATHOGENESIS; INHIBITION; VERAPAMIL; ASSAY;

D O I：

10.1016/j.clineuro.2010.08.015

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

About 80 years have passed since the first cases of organophosphate induced delayed polyneuropathy (OPIDP), as the consequence of human poisoning with certain organophosphorus compounds, were described in the literature. OPIDP is a relatively rare neurodegenerative disorder in humans characterized by loss of function, ataxia and paralysis of distal parts of sensory and motor axons in peripheral nerves and ascending and descending tracts of spinal cord appearing 2-3 weeks after exposure or later. The molecular target for OPIDP is considered to be an enzyme in the nervous system known as neuropathy target esterase (NTE). This review discusses OPIDP in man with emphasis on clinical presentation, pathogenesis, molecular mechanisms, and possibilities for prevention/therapy. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：7 / 10

页数：4

共 48 条

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