Biochemical Recurrence in Prostate Cancer: The European Association of Urology Prostate Cancer Guidelines Panel Recommendations

被引：180

作者：

Van den Broeck, Thomas ^{[1
]}

van den Bergh, Roderick C. N. ^{[2
]}

Briers, Erik

Cornford, Philip ^{[3
]}

Cumberbatch, Marcus ^{[4
]}

Tilki, Derya ^{[5
,6
]}

De Santis, Maria ^{[7
,8
]}

Fanti, Stefano ^{[9
]}

Fossati, Nicola ^{[10
,11
]}

Gillessen, Silke ^{[12
,13
,14
,15
]}

Grummet, Jeremy P. ^{[16
]}

Henry, Ann M. ^{[17
]}

Lardas, Michael ^{[18
]}

Liew, Matthew ^{[19
]}

Mason, Malcolm ^{[20
]}

Moris, Lisa ^{[1
,21
]}

Schoots, Ivo G. ^{[22
]}

van der Kwast, Theodorus ^{[23
]}

van der Poel, Henk ^{[24
]}

Wiegel, Thomas ^{[25
]}

Willemse, Peter-Paul M. ^{[26
]}

Rouviere, Olivier ^{[27
]}

Lam, Thomas B. ^{[28
,29
]}

Mottet, Nicolas ^{[30
]}

机构：

[1] Univ Hosp Leuven, Dept Urol, Herestr 49, B-3000 Leuven, Belgium

[2] St Antonius Hosp, Utrecht, Netherlands

[3] Royal Liverpool & Broadgreen Hosp NHS Trust, Liverpool, Merseyside, England

[4] Univ Sheffield, Acad Urol Unit, Sheffield, S Yorkshire, England

[5] Univ Hosp Hamburg Eppendorf, Martini Klin Prostate Canc Ctr, Hamburg, Germany

[6] Univ Hosp Hamburg Eppendorf, Dept Urol, Hamburg, Germany

[7] Charite, Berlin, Germany

[8] Med Univ Vienna, Dept Urol, Vienna, Austria

[9] Univ Bologna, Policlin S Orsola, Nucl Med Div, Bologna, Italy

[10] IRCCS, Osped San Raffaele, Urol Res Inst, Unit Urol Div Oncol, Milan, Italy

[11] Univ Vita Salute San Raffaele, Milan, Italy

[12] Univ Manchester, Div Canc Sci, Manchester, Lancs, England

[13] Christie, Manchester, Lancs, England

[14] Cantonal Hosp St Gallen, Dept Oncol & Haematol, St Gallen, Switzerland

[15] Univ Bern, Bern, Switzerland

[16] Monash Univ, Cent Clin Sch, Dept Surg, Melbourne, Vic, Australia

[17] Univ Leeds, St Jamess Univ Hosp, Leeds Canc Ctr, Leeds, W Yorkshire, England

[18] Leto Hosp, Dept Urol, Athens, Greece

[19] Wigan & Leigh NHS Fdn Trust, Dept Urol, Wigan, England

[20] Cardiff Univ, Sch Med, Cardiff, Wales

[21] Katholieke Univ Leuven, Lab Mol Endocrinol, Leuven, Belgium

[22] Erasmus MC, Univ Med Ctr, Dept Radiol & Nucl Med, Rotterdam, Netherlands

[23] Erasmus MC, Dept Pathol, Rotterdam, Netherlands

[24] Netherlands Canc Inst, Dept Urol, Amsterdam, Netherlands

[25] Univ Hosp Ulm, Dept Radiat Oncol, Ulm, Germany

[26] Univ Med Ctr, Utrecht Canc Ctr, Dept Oncol Urol, Utrecht, Netherlands

[27] Hosp Civils Lyon, Edouard Herriot Hosp, Radiol Dept, Lyon, France

[28] Univ Aberdeen, Acad Urol Unit, Aberdeen, Scotland

[29] Aberdeen Royal Infirm, Dept Urol, Aberdeen, Scotland

[30] Univ Hosp, Dept Urol, St Etienne, France

来源：

EUROPEAN UROLOGY FOCUS | 2020年 / 6卷 / 02期

基金：

英国医学研究理事会;

关键词：

Prostate cancer; Biochemical recurrence; Radical prostatectomy; Radiotherapy; Gleason score; PSA kinetics; Prognostic factors; Guidelines; European Association of Urology; SALVAGE RADIATION-THERAPY; RADICAL PROSTATECTOMY; SURVIVAL; FAILURE; RADIOTHERAPY; ANTIGEN; IMPACT; PROGRESSION; ADJUVANT; DEATH;

D O I：

10.1016/j.euf.2019.06.004

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Biochemical recurrence (BCR) after primary treatment of localized prostate cancer does not necessarily lead to clinically apparent progressive disease. To aid in prognostication, the European Association of Urology prostate cancer guidelines panel undertook a systematic review and successfully developed a novel BCR risk stratification system (groups with a low risk or high risk of BCR) based on disease and prostate-specific antigen characteristics. Patient summary: Following treatment to cure prostate cancer, some patients can develop recurrence of disease identified via a prostate-specific antigen blood test (ie, biochemical recurrence, or BCR). However, not every man who experiences BCR develops progressive disease (symptoms or evidence of disease progression on imaging). We conducted a review of the literature and developed a classification system for predicting which patients might progress to optimize treatment decisions. (C) 2019 European Association of Urology. Published by Elsevier B.V. All rights reserved.

引用

页码：231 / 234

页数：4

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