Determination of Zinc Oxide in Pharmaceutical Preparations by EDTA Titration: A Practical Class for a Quantitative Analysis Course

被引：20

作者：

Simoes, Gustavo Borges ^{[1
]}

Victor e Silva Badolato, Paulo ^{[1
]}

Ignacio, Marcelo Dante ^{[1
]}

Cerqueira, Eduardo Coelho ^{[1
]}

机构：

[1] Inst Fed Educ Ciencia & Tecnol Rio de Janeiro, BR-20270021 Rio De Janeiro, Brazil

来源：

JOURNAL OF CHEMICAL EDUCATION | 2020年 / 97卷 / 02期

关键词：

Second-Year Undergraduate; Upper-Division Undergraduate; Analytical Chemistry; Laboratory Instruction; Hands-On Learning/Manipulatives; Titration/Volumetric Analysis; Coordination Compounds; RAPID SPECTROPHOTOMETRIC DETERMINATION; CETYLPYRIDINIUM CHLORIDE; CALCIUM; WATER;

D O I：

10.1021/acs.jchemed.9b00939

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Zinc oxide is a common additive in food, cosmetics, and medicines. Here, we describe the validation of methods to analyze two pharmaceutical samples containing ZnO-talc powder and dermal ointment-by ethylenediaminetetraacetic acid (EDTA) titration. The methods developed were implemented as a practical class to students of a Quantitative Analysis course, and the statistical analysis of the results were performed with the students in order to compare experimental results with label information. The practical class allowed students to see an interesting application of EDTA titration in quality control and provided better practical comprehension of important contents in complexometric titrations, statistical analysis, and laboratory techniques.

引用

页码：522 / 527

页数：11