Regioselectivity and enantioselectivity in nickel-catalysed reductive coupling reactions of alkynes

被引：183

作者：

Moslin, Ryan M.

Miller-Moslin, Karen

Jamison, Timothy F. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

[2] Novartis Inst Biomed Res Inc, Global Discovery Chem Oncol Div, Cambridge, MA USA

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 43期

关键词：

D O I：

10.1039/b707737h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nickel-catalysed reductive coupling reactions of alkynes have emerged as powerful synthetic tools for the selective preparation of functionalized alkenes. One of the greatest challenges associated with these transformations is control of regioselectivity. Recent work from our laboratory has provided an improved understanding of several of the factors governing regioselectivity in these reactions, and related studies have revealed that the reaction mechanism can differ substantially depending on the ligand employed. A discussion of stereoselective transformations and novel applications of nickel catalysis in coupling reactions of alkynes is also included.

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页码：4441 / 4449

页数：9

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