Normalized power prior Bayesian analysis

被引:15
作者
Ye, Keying [1 ]
Han, Zifei [2 ]
Duan, Yuyan [3 ]
Bai, Tianyu [4 ]
机构
[1] Univ Texas San Antonio, Dept Management Sci & Stat, San Antonio, TX USA
[2] Univ Int Business & Econ, Sch Stat, Beijing, Peoples R China
[3] Novartis Inst BioMed Res, Cambridge, MA USA
[4] US FDA, Silver Spring, MD USA
关键词
Bayesian analysis; Historical data; Joint power prior; Normalized power prior; Kullback-Leibler divergence; EVALUATING CARDIOVASCULAR RISK; CLINICAL-TRIALS; NONINFERIORITY TRIALS; PRIOR DISTRIBUTIONS; NON-INFERIORITY; DESIGN;
D O I
10.1016/j.jspi.2021.05.005
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
The elicitation of power priors, based on the availability of historical data, is realized by raising the likelihood function of the historical data to a fractional power delta, which quantifies the degree of discounting of the historical information in making inference with the current data. When delta is not pre-specified and is treated as random, it can be estimated from the data using Bayesian updating paradigm. However, in the original form of the joint power prior Bayesian approach, certain positive constants before the likelihood of the historical data could be multiplied when different settings of sufficient statistics are employed. This would change the power priors with different constants, and hence the likelihood principle is violated. In this article, we investigate a normalized power prior approach which obeys the likelihood principle and is a modified form of the joint power prior. The optimality properties of the normalized power prior in the sense of minimizing the weighted Kullback-Leibler divergence are investigated. By examining the posteriors of several commonly used distributions, we show that the discrepancy between the historical and the current data can be well quantified by the power parameter under the normalized power prior setting. Efficient algorithms to compute the scale factor is also proposed. In addition, we illustrate the use of the normalized power prior Bayesian analysis with three data examples, and provide an implementation with an R package NPP. (C) 2021 Elsevier B.V. All rights reserved.
引用
收藏
页码:29 / 50
页数:22
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