Metabolic Remodeling in Skeletal Muscle Atrophy as a Therapeutic Target

被引：9

作者：

Renzini, Alessandra ^{[1
]}

Riera, Carles Sanchez ^{[1
]}

Minic, Isidora ^{[1
]}

D'Ercole, Chiara ^{[1
]}

Lozanoska-Ochser, Biliana ^{[1
]}

Cedola, Alessia

Gigli, Giuseppe

Moresi, Viviana ^{[1
]}

Madaro, Luca ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Anat, Unit Histol & Med Embryol, Histol, I-00185 Rome, Italy

来源：

METABOLITES | 2021年 / 11卷 / 08期

关键词：

skeletal muscle metabolism; muscle wasting; physical exercise; diet; epigenetics; AMYOTROPHIC-LATERAL-SCLEROSIS; POLYUNSATURATED FATTY-ACIDS; MITOCHONDRIAL PROTEIN-SYNTHESIS; VITAMIN-D SUPPLEMENTATION; FIBER-TYPE SPECIFICITY; CHAIN AMINO-ACIDS; BODY-MASS INDEX; CANCER CACHEXIA; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY;

D O I：

10.3390/metabo11080517

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Skeletal muscle is a highly responsive tissue, able to remodel its size and metabolism in response to external demand. Muscle fibers can vary from fast glycolytic to slow oxidative, and their frequency in a specific muscle is tightly regulated by fiber maturation, innervation, or external causes. Atrophic conditions, including aging, amyotrophic lateral sclerosis, and cancer-induced cachexia, differ in the causative factors and molecular signaling leading to muscle wasting; nevertheless, all of these conditions are characterized by metabolic remodeling, which contributes to the pathological progression of muscle atrophy. Here, we discuss how changes in muscle metabolism can be used as a therapeutic target and review the evidence in support of nutritional interventions and/or physical exercise as tools for counteracting muscle wasting in atrophic conditions.

引用

页数：26

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