Metabolic Remodeling in Skeletal Muscle Atrophy as a Therapeutic Target

被引:8
作者
Renzini, Alessandra [1 ]
Riera, Carles Sanchez [1 ]
Minic, Isidora [1 ]
D'Ercole, Chiara [1 ]
Lozanoska-Ochser, Biliana [1 ]
Cedola, Alessia
Gigli, Giuseppe
Moresi, Viviana [1 ]
Madaro, Luca [1 ]
机构
[1] Sapienza Univ Rome, Dept Anat, Unit Histol & Med Embryol, Histol, I-00185 Rome, Italy
关键词
skeletal muscle metabolism; muscle wasting; physical exercise; diet; epigenetics; AMYOTROPHIC-LATERAL-SCLEROSIS; POLYUNSATURATED FATTY-ACIDS; MITOCHONDRIAL PROTEIN-SYNTHESIS; VITAMIN-D SUPPLEMENTATION; FIBER-TYPE SPECIFICITY; CHAIN AMINO-ACIDS; BODY-MASS INDEX; CANCER CACHEXIA; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY;
D O I
10.3390/metabo11080517
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Skeletal muscle is a highly responsive tissue, able to remodel its size and metabolism in response to external demand. Muscle fibers can vary from fast glycolytic to slow oxidative, and their frequency in a specific muscle is tightly regulated by fiber maturation, innervation, or external causes. Atrophic conditions, including aging, amyotrophic lateral sclerosis, and cancer-induced cachexia, differ in the causative factors and molecular signaling leading to muscle wasting; nevertheless, all of these conditions are characterized by metabolic remodeling, which contributes to the pathological progression of muscle atrophy. Here, we discuss how changes in muscle metabolism can be used as a therapeutic target and review the evidence in support of nutritional interventions and/or physical exercise as tools for counteracting muscle wasting in atrophic conditions.
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页数:26
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