Sepsis and septic shock: New definitions, new diagnostic and therapeutic approaches

被引：150

作者：

Esposito, Silvano ^{[1
]}

De Simone, Giuseppe ^{[1
]}

Boccia, Giovanni ^{[2
]}

De Caro, Francesco ^{[2
]}

Pagliano, Pasquale ^{[3
]}

机构：

[1] Univ Salerno, Dept Infect Dis, Salerno, Italy

[2] Univ Salerno, Inst Hygene, Salerno, Italy

[3] AORN Colli, Dept Infect Dis, Naples, Italy

来源：

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE | 2017年 / 10卷

关键词：

Sepsis; Septic shock; Epidemiology; Biomarkers; Antibiotic treatment; INTERNATIONAL CONSENSUS DEFINITIONS; ORGAN FAILURE ASSESSMENT; BLOOD-STREAM INFECTIONS; IN-HOSPITAL MORTALITY; INTENSIVE-CARE UNITS; ANTIBIOTIC-RESISTANCE; EPIDEMIOLOGY; MANAGEMENT; GUIDELINES; OUTCOMES;

D O I：

10.1016/j.jgar.2017.06.013

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Sepsis and septic shock are common life-threatening pathologies associated with high mortality and substantial costs for healthcare system. Clinical guidelines and bundles for the management of patients with sepsis have recently been updated. Herein, we review the history of sepsis and related conditions definitions from the first consensus conference in 1991 to nowadays, the epidemiologic data resulting from worldwide studies on incidence and mortality, the diagnostic approaches including the microbiological assessment of infection and the use of several prognostic and diagnostic biomarkers and finally we review the main therapeutic measures as the intravenous immunoglobulin therapy and the administration of appropriate antibiotic treatment to provide patients with sepsis a favourable outcome in the antibiotic-resistance era. (C) 2017 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.

引用

页码：204 / 212

页数：9

共 95 条

[1] Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock [J].