A Novel Approach to Label-free Detection of DNA Hybridization Based on Graphene Quantum Capacitance dependent Frequency/Wireless Readout

Graphene is an atomic layer thin two dimensional material with unique electrical and mechanical properties. Due to its high sensitivity, high conductivity, high carrier mobility, low intrinsic noises and high signal to noise ratio, it is being used in various sensing application. DNA Hybridization sensing is a key tool for genetic research as well as for detection of deadly diseases like Cancer, Hepatitis B and other complex hereditary diseases. There are various methods of DNA hybridization detection. One of the label free DNA hybridization detection methods is frequency readout. In this paper graphene quantum capacitance based frequency readout for label free DNA hybridization detection is proposed where graphene is used as the sensing material. This work shows that the mismatched and complementary DNA strands results in distinguished frequency range and the frequency output is almost linear with respect to concentration of DNA.