Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction JACC State-of-the-Art Review

被引：123

作者：

Pandey, Ambarish ^{[1
]}

Shah, Sanjiv J. ^{[2
]}

Butler, Javed ^{[3
]}

Kellogg, Dean L. ^{[4
]}

Lewis, Gregory D. ^{[5
]}

Forman, Daniel E. ^{[6
]}

Mentz, Robert J. ^{[7
]}

Borlaug, Barry A. ^{[8
]}

Simon, Marc A. ^{[6
]}

Chirinos, Julio A. ^{[9
]}

Fielding, Roger A. ^{[10
]}

Volpi, Elena ^{[11
]}

Molina, Anthony J. A. ^{[12
]}

Haykowsky, Mark J. ^{[13
]}

Sam, Flora ^{[14
]}

Goodpaster, Bret H. ^{[15
]}

Bertoni, Alain G. ^{[16
]}

Justice, Jamie N. ^{[16
]}

White, James P. ^{[17
]}

Ding, Jingzhone ^{[16
]}

Hummel, Scott L. ^{[18
]}

LeBrasseur, Nathan K. ^{[8
]}

Taffet, George E. ^{[19
]}

Pipinos, Iraklis I. ^{[20
]}

Kitzman, Dalane ^{[16
]}

机构：

[1] Univ Texas Southwestern Med Ctr, Dallas, TX USA

[2] Northwestern Univ Feinberg Sch Med, Chicago, IL USA

[3] Univ Mississippi Med Ctr, Jackson, MS USA

[4] Univ Texas Hlth Sci Ctr & GRECC, South Texas Vet Affairs Hlth Syst, San Antonio, TX USA

[5] Massachusetts Gen Hosp, Boston, MA USA

[6] Univ Pittsburgh & VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA

[7] Duke Clin Res Ctr, Durham, NC USA

[8] Mayo Clin, Rochester, MN USA

[9] Univ Penn, Philadelphia, PA USA

[10] Tufts Univ, Boston, MA USA

[11] Univ Texas Med Branch Galveston, Galveston, TX USA

[12] Univ Calif San Diego, San Diego, CA USA

[13] Univ Alberta, Edmonton, AB, Canada

[14] Boston Univ Sch Med, Boston, MA USA

[15] Advent Hlth Translat Res Inst, Orlando, FL USA

[16] Wake Forest Sch Med, Winston Salem, NC USA

[17] Duke Univ, Durham, NC USA

[18] Univ Michigan & VA Ann Arbor Hlth Syst, Ann Arbor, MI USA

[19] Baylor Coll Med, Houston, TX USA

[20] Univ Nebraska Med Ctr, Omaha, NE USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2020年 / 78卷 / 11期

关键词：

exercise intolerance; heart failure with preserved ejection fraction; senescence; skeletal muscle; aging; PLASMINOGEN-ACTIVATOR INHIBITOR-1; CALORIE RESTRICTION; ADIPOSE-TISSUE; OXYGEN-CONSUMPTION; PHYSICAL-ACTIVITY; OXIDATIVE STRESS; AEROBIC CAPACITY; NITRIC-OXIDE; LIFE-SPAN; MUSCLE;

D O I：

10.1016/j.jacc.2021.07.014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Exercise intolerance (EI) is the primary manifestation of chronic heart failure with preserved ejection fraction (HFpEF), the most common form of heart failure among older individuals. The recent recognition that HFpEF is likely a systemic, multiorgan disorder that shares characteristics with other common, difficult-to-treat, aging-related disorders suggests that novel insights may be gained from combining knowledge and concepts from aging and cardiovascular disease disciplines. This state-of-the-art review is based on the outcomes of a National Institute of Aging-sponsored working group meeting on aging and EI in HFpEF. We discuss aging-related and extracardiac contributors to EI in HFpEF and provide the rationale for a transdisciplinary, "gero-centric" approach to advance our understanding of EI in HFpEF and identify promising new therapeutic targets. We also provide a framework for prioritizing future research, including developing a uniform, comprehensive approach to phenotypic characterization of HFpEF, elucidating key geroscience targets for treatment, and conducting proof-of-concept trials to modify these targets. (J Am Coll Cardiol 2021;78:1166-1187) (c) 2021 by the American College of Cardiology Foundation.

引用

页码：1166 / 1187

页数：22

共 130 条

[1] Coronary microvascular dysfunction is associated with exertional haemodynamic abnormalities in patients with heart failure with preserved ejection fraction [J].