Personalised Advanced Therapies in Parkinson's Disease: The Role of Non-Motor Symptoms Profile

被引：30

作者：

Leta, Valentina ^{[1
,2
]}

Dafsari, Haidar S. ^{[3
]}

Sauerbier, Anna ^{[1
,2
,3
]}

Metta, Vinod ^{[1
,2
]}

Titova, Nataliya ^{[4
,5
]}

Timmermann, Lars ^{[6
]}

Ashkan, Keyoumars ^{[7
]}

Samuel, Michael ^{[2
]}

Pekkonen, Eero ^{[8
]}

Odin, Per ^{[9
]}

Antonini, Angelo ^{[10
]}

Martinez-Martin, Pablo ^{[11
]}

Parry, Miriam ^{[1
,2
]}

van Wamelen, Daniel J. ^{[1
,2
,12
]}

Ray Chaudhuri, K. ^{[1
,2
]}

机构：

[1] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Basic & Clin Neurosci, London SE5 9RT, England

[2] Kings Coll Hosp London, Parkinsons Fdn Ctr Excellence, London SE5 9RS, England

[3] Univ Cologne, Dept Neurol, Fac Med, D-50937 Cologne, Germany

[4] NI Pirogov Russian Natl Res Med Univ, Dept Neurol Neurosurg & Med Genet, Fed State Autonomous Educ Inst Higher Educ, Minist Hlth Russian Federat, Moscow 117997, Russia

[5] Fed Ctr Brain & Neurotechnol, Fed State Budgetary Inst, Dept Neurodegenerat Dis, Minist Hlth Russian Federat, Moscow 117997, Russia

[6] Univ Hosp Giessen & Marburg, Dept Neurol, Campus Marburg, D-35043 Marburg, Germany

[7] Kings Coll Hosp Fdn Trust, Dept Neurosurg, London SE5 9RS, England

[8] Univ Helsinki, Dept Neurol, Helsinki 00029, Finland

[9] Lund Univ, Dept Clin Sci, Div Neurol, P663 Q9, Lund, Sweden

[10] Univ Padua, Parkinson & Movement Disorders Unit, Dept Neurosci, I-35138 Padua, Italy

[11] Carlos III Inst Hlth, Ctr Networked Biomed Res Neurodegenerat Dis CIBER, Madrid 28031, Spain

[12] Radboud Univ Nijmegen, Med Ctr, Dept Neurol, Donders Inst Brain Cognit & Behav, NL-6500 HB Nijmegen, Netherlands

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2021年 / 11卷 / 08期

关键词：

Parkinson's disease; device-aided therapies; non-motor symptoms; personalised medicine; apomorphine; levodopa-carbidopa intestinal gel; deep brain stimulation; DEEP-BRAIN-STIMULATION; CARBIDOPA INTESTINAL GEL; INTRAJEJUNAL LEVODOPA INFUSION; SUBCUTANEOUS APOMORPHINE; MOTOR; NEUROSTIMULATION; COMPLICATIONS; MULTICENTER; IMPACT; FORCE;

D O I：

10.3390/jpm11080773

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Device-aided therapies, including levodopa-carbidopa intestinal gel infusion, apomorphine subcutaneous infusion, and deep brain stimulation, are available in many countries for the management of the advanced stage of Parkinson's disease (PD). Currently, selection of device-aided therapies is mainly focused on patients' motor profile while non-motor symptoms play a role limited to being regarded as possible exclusion criteria in the decision-making process for the delivery and sustenance of a successful treatment. Differential beneficial effects on specific non-motor symptoms of the currently available device-aided therapies for PD are emerging and these could hold relevant clinical implications. In this viewpoint, we suggest that specific non-motor symptoms could be used as an additional anchor to motor symptoms and not merely as exclusion criteria to deliver bespoke and patient-specific personalised therapy for advanced PD.

引用

页数：11

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