Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor

被引：192

作者：

Mosnier, LO ^{[1
]}

Griffin, JH ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

来源：

BIOCHEMICAL JOURNAL | 2003年 / 373卷

关键词：

activated protein C; apoptosis; endothelial cell protein C receptor (EPCR); protease-activated receptor (PAR);

D O I：

10.1042/BJ20030341

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In a model of staurosporine-induced apoptosis using EAhy926 endothelial cells, inhibition of apoptosis by activated protein C was dose-dependent and required the enzyme's active site, implicating activated protein C-mediated proteolysis. Consistent with this implication, both protease-activated receptor-1 (PAR-1) and endothelial cell protein C receptor (EPCR) were required for the anti-apoptotic effects of activated protein C.

引用

页码：65 / 70

页数：6

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