The tale of tail-anchored proteins: coming from the cytosol and looking for a membrane

被引:210
作者
Borgese, N
Colombo, S
Pedrazzini, E
机构
[1] CNR, Inst Neurosci, Cellular & Mol Pharmacol Sect, I-20129 Milan, Italy
[2] Univ Milan, Dept Med Pharmacol, I-20129 Milan, Italy
[3] Univ Catanzaro Magna Grecia, Fac Pharm, I-88021 Roccelletta Di Borgia, CZ, Italy
[4] CNR, Inst Biol & Biotechnol Agraria, I-20133 Milan, Italy
关键词
endoplasmic reticulum; membrane traffic; mitochondrial outer membrane; protein targeting and translocation; transmembrane domain;
D O I
10.1083/jcb.200303069
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
A group of integral membrane proteins, known as C-tail anchored, is defined by the presence of a cytosolic NH2-terminal domain that is anchored to the phospholipid bilayer by a single segment of hydrophobic amino acids close to the COOH terminus. The mode of insertion into membranes of these proteins, many of which play key roles in fundamental intracellular processes, is obligatorily posttranslational, is highly specific, and may be subject to regulatory processes that modulate the protein's function. Although recent work has elucidated structural features in the tail region that determine selection of the correct target membrane, the molecular machinery involved in interpreting this information, and in modulating tail-anchored protein localization, has not been identified yet.
引用
收藏
页码:1013 / 1019
页数:7
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