Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections

被引：214

作者：

Ma, Yu-Xuan ^{[1
]}

Wang, Chen-Yu ^{[1
]}

Li, Yuan-Yuan ^{[1
]}

Li, Jing ^{[1
]}

Wan, Qian-Qian ^{[1
]}

Chen, Ji-Hua ^{[1
]}

Tay, Franklin R. ^{[1
,2
]}

Niu, Li-Na ^{[1
,2
]}

机构：

[1] Fourth Mil Med Univ, Natl Clin Res Ctr Oral Dis, State Key Lab Mil Stomatol, Shaanxi Key Lab Stomatol,Sch Stomatol,Dept Prosth, 145 Changle West Rd, Xian 710032, Shaanxi, Peoples R China

[2] Augusta Univ, Grad Sch, 1430 John Wesley Gilbert Dr, Augusta, GA 30912 USA

来源：

ADVANCED SCIENCE | 2020年 / 7卷 / 01期

关键词：

antimicrobial peptides; antiresistance; antivirulence; bacteriophages; nanodelivery strategies; RESISTANT-STAPHYLOCOCCUS-AUREUS; ACUTE BACTERIAL SKIN; URINARY-TRACT-INFECTIONS; ANTIMICROBIAL PHOTODYNAMIC INACTIVATION; POLYMER HYBRID NANOPARTICLES; HUMAN-MILK OLIGOSACCHARIDES; INTENSIVE-CARE-UNIT; COMPLICATED INTRAABDOMINAL INFECTIONS; PSEUDOMONAS-AERUGINOSA INFECTION; ACYL HOMOSERINE LACTONES;

D O I：

10.1002/advs.201901872

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are among the most common opportunistic pathogens in nosocomial infections. ESKAPE pathogens distinguish themselves from normal ones by developing a high level of antibiotic resistance that involves multiple mechanisms. Contemporary therapeutic strategies which are potential options in combating ESKAPE bacteria need further investigation. Herein, a broad overview of the antimicrobial research on ESKAPE pathogens over the past five years is provided with prospective clinical applications.

引用

页数：43

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