Identification of unique in-frame deletions in OprD among clinical isolates of Pseudomonas aeruginosa

被引：14

作者：

Kos, Veronica N. ^{[1
]}

McLaughlin, Robert E. ^{[1
]}

Gardner, Humphrey A. ^{[2
]}

机构：

[1] AstraZeneca R&D Boston, Infect Innovat Med Unit, 35 Gatehouse Dr, Waltham, MA 02451 USA

[2] AstraZeneca R&D Boston, Early Clin Dev Innovat Med Unit, Waltham, MA 02451 USA

来源：

PATHOGENS AND DISEASE | 2016年 / 74卷 / 04期

关键词：

Pseudomonas aerguinosa; porin; OprD; carbapenem resistance; OUTER-MEMBRANE; PORIN OPRD; RESISTANCE; PROTEIN; SYSTEM; SITE; SUSCEPTIBILITY; MUTAGENESIS; DIFFUSION;

D O I：

10.1093/femspd/ftw031

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A large percentage of Pseudomonas aeruginosa clinical isolates have been noted to be resistant to carbapenems due to loss of function of the OprD porin, the primary mechanism of entry for carbapenems. Such modifications also substantially abolish the organism's ability to transport arginine. Here we report the identification of an in-frame deletion in oprD which confers carbapenem resistance but is expressed and retains the ability to transport arginine.

引用

页数：4

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