Evaluation of MWCNTs/TiO2/Chitosan Composite as a Carbon Paste Electrode for the Determination of Pazufloxacin

被引：16

作者：

Abdallah, Nehad A. ^{[1
,2
]}

Ahmed, Sameh ^{[1
,3
]}

机构：

[1] Taibah Univ, Fac Pharm, Pharmacognosy & Pharmaceut Chem Dept, Al Madinah Al Mounawarah 41477, Saudi Arabia

[2] Ain Shams Univ, Fac Pharm, Expt & Adv Pharmaceut Res Unit, Cairo 1156, Egypt

[3] Assiut Univ, Fac Pharm, Dept Pharmaceut Analyt Chem, Assiut 71526, Egypt

来源：

JOURNAL OF THE ELECTROCHEMICAL SOCIETY | 2018年 / 165卷 / 11期

关键词：

TIO2; NANOPARTICLES; NANOTUBES; MESILATE; CHEMILUMINESCENCE; ADSORPTION; QUINOLONES; MESYLATE;

D O I：

10.1149/2.1151811jes

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

New carbon paste electrode for pazufloxacin mesylate determination modified with MWCNTs/TiO2/Chitosan nanocomposite was developed. It was based on the covalent linkage of chitosan to the MWCNTs/TiO2 nanoparticle surface to enhance the sensor electrical properties, sensitivity and selectivity. The prepared nanocomposite was characterized by Fourier transform-Infrared, X-ray diffraction, Transmission electron microscope and Thermal gravimetric analysis. The sensor under optimal conditions exhibited high accuracy, precision and reproducibility with a stability of 123 days. It was efficiently applied for the determination of pazufloxacin mesylate in pure standard solution and spiked human plasma. It showed a linearity range of 1 x 10(-9) to 1 x 10(-3) mol L-1 with a correlation coefficient of 0.994 and a nernestian slope of 56.76 mV/concentration decade. The LOD was 4.8 x 10(-10) mol L-1. (c) 2018 The Electrochemical Society.

引用

页码：H756 / H763

页数：8

共 32 条

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[2]

BRIGHTY KE, 2000, QUINOLONES

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