To examine the predictive power of Cloninger's psychobiology model of depression, 167 Japanese college students were studied on two occasions, with an interval of approximately three months. At Time 1 (T1). the Temperament and Character inventory (TCI) and Self-rating Depression Scale (SDS) were distributed. At Time 2 (T2), the SDS was distributed again. The T2 SDS score was positively correlated with Harm Avoidance and negatively correlated with Reward Dependence and Self-directedness at T1. However. after controlling for the T1 SDS score, the T2 SDS score was predicted only by T1 Self-directedness. These data suggest that lower Self-directedness can be predictive of depression, whereas higher Harm Avoidance and lower Reward Dependence are state-dependent. (C) 2000 John Wiley & Sons. Inc.