Malignant fibrous histiocytoma of the liver: A case report and review of the literature

Malignant fibrous histiocytoma (MFH) is a common soft tissue sarcoma, usually occurring in the extremities. NFH of the liver is an extremely rare neoplasm, with only 28 cases reported in the international literature since 1985. We present a case of MFH of the liver in an 87-year-old woman. The tumor was located in the right lobe of the liver and measured 12 x 8 cm. It consisted of spindle-shaped, pleomorphic, malignant cells in a storiform pattern associated with histiocyte-like cells and giant cells. Most of the tumor cells and giant cells were vimentin and (alpha(1)-antichymotrypsin positive. Histopathological findings were consistent with an MFH of the storiform / pleomorphic subtype. The literature is briefly reviewed.