Catalyst-free multi-component cascade C-H-functionalization in water using molecular oxygen: an approach to 1,3-oxazines

被引：54

作者：

Deb, Mohit L. ^{[1
]}

Pegu, Choitanya D. ^{[1
]}

Borpatra, Paran J. ^{[1
]}

Saikia, Prakash J. ^{[2
]}

Baruah, Pranjal K. ^{[1
]}

机构：

[1] Gauhati Univ, Dept Appl Sci, GUIST, Gauhati 781014, Assam, India

[2] CSIR NEIST, Analyt Chem Div, Jorhat 785006, India

来源：

GREEN CHEMISTRY | 2017年 / 19卷 / 17期

关键词：

DEHYDROGENATIVE-COUPLING REACTION; REVERSE-TRANSCRIPTASE INHIBITORS; N-ARYL-TETRAHYDROISOQUINOLINES; CARBON-HYDROGEN BONDS; TERTIARY-AMINES; METAL-FREE; OXIDATIVE AMINATION; NITROGEN ATOM; SODIUM-CYANIDE; MUSCARINIC RECEPTORS;

D O I：

10.1039/c7gc01494e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, catalyst-free 3-component reactions of naphthols, aldehydes, and tetrahydroisoquinolines to synthesize 1,3-oxazines is reported. The reaction is performed in H2O in the presence of O-2 as the sole oxidant at 100 degrees C, which proceeds through the formation of 1-aminoalkyl-2-naphthols followed by selective alpha-C-H functionalization of tert-amine.

引用

页码：4036 / 4042

页数：7

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