Gene Modified T Cell Therapies for Hematological Malignancies

被引：5
|
作者：
Abramowski-Mock, Ulrike [1 ]
Delhove, Juliette M. [1 ]
Qasim, Waseem [1 ]
机构：
[1] UCL, Mol & Cellular Immunol Unit, UCL Great Ormond St Inst Child Hlth, 30 Guilford St, London WC1N 1EH, England
来源：
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2017年 / 31卷 / 05期
基金：
“创新英国”项目;
关键词：
Gene therapy; Gene editing; Adoptive immunotherapy; T cell receptor; Chimeric antigen receptor; Lentiviral vectors; Leukemia; Lymphoma; CHIMERIC-ANTIGEN-RECEPTOR; ACUTE MYELOID-LEUKEMIA; ZINC-FINGER NUCLEASES; B-CELL; CANCER-IMMUNOTHERAPY; ADOPTIVE IMMUNOTHERAPY; IMMUNE CHECKPOINTS; MULTIPLE-MYELOMA; CLINICAL-TRIAL; LYMPHOCYTES;
D O I：
10.1016/j.hoc.2017.06.005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This article focuses on clinical applications of T cells transduced to express recombinant T-cell receptor and chimeric antigen receptor constructs directed toward hematological malignancies, and considers newer strategies incorporating gene-editing technologies to address graft-versus-host disease and host-mediated rejection. Recent data from clinical trials are reviewed, and an overview is provided of current and emerging manufacturing processes; consideration is also given to new developments in the pipeline.
引用
收藏
页码：913 / +
页数：15
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