Micromachine-Enabled Capture and Isolation of Cancer Cells in Complex Media

被引：334
作者：
Balasubramanian, Shankar [1 ]
Kagan, Daniel [1 ]
Hu, Che-Ming Jack [1 ]
Campuzano, Susana [1 ]
Lobo-Castanon, M. Jesus [1 ]
Lim, Nicole [1 ]
Kang, Dae Y. [1 ]
Zimmerman, Maria [1 ]
Zhang, Liangfang [1 ]
Wang, Joseph [1 ]
机构：
[1] Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 18期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
antibodies; cancer; micromachines; CIRCULATING TUMOR-CELLS; COLLOIDAL CARGO; NANOMOTORS; TRANSPORT; DELIVERY; MOTION; BLOOD;
D O I：
10.1002/anie.201100115
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Microrockets detect cancer: A micromachine is used for the in vitro isolation of pancreatic cancer cells in complex media. The strategy is based on the selective binding and transport ability of antibody-functionalized microengine rockets: these microrockets selectively recognize the surface antigens overexpressed by pancreatic cancer cells, and capture and transport the cancer cells over a preselected path (see picture). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：4161 / 4164
页数：4
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