Permeation modulating properties of natural polymers - Effect of molecular weight and mucus

被引：18

作者：

Hagesaether, Ellen ^{[1
]}

机构：

[1] Univ So Denmark, Inst Chem & Phys, DK-5230 Odense M, Denmark

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2011年 / 409卷 / 1-2期

关键词：

Pectin; Hyaluronic acid; Chitosan; Permeation modulating; Mucus; HT29-MTX; CELL-LINES; ABSORPTION; CHITOSAN; ENHANCEMENT; HT29-MTX; GROWTH; CACO-2;

D O I：

10.1016/j.ijpharm.2011.02.046

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The permeation modulating effects of 5 natural polymers; low-ester, amidated and high-ester pectin, as well as hyaluronic acid and chitosan were tested at two different molecular weights each. The model membrane was methotrexate treated HT29 cells grown for 2 or 3 weeks, respectively, thereby differing in the amount of goblet cells and hence mucus. The pectins decreased the permeation of the paracellular marker carboxyfluorescein. Free acid groups and a high molecular weight increased this membrane protective effect. Chitosan displayed pronounced and hyaluronic acid modest permeation enhancing properties. In this case, a low molecular weight accentuated the effect. In all cases, the permeation modulating properties were reduced by mucus. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：150 / 155

页数：6

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