BXD Recombinant Inbred Mice as a Model to Study Neurotoxicity

被引：11

作者：

Martins, Airton C. ^{[1
]}

Lopez-Granero, Caridad ^{[2
]}

Ferrer, Beatriz ^{[1
]}

Tinkov, Alexey A. ^{[3
,4
]}

Skalny, Anatoly V. ^{[5
,6
]}

Paoliello, Monica M. B. ^{[1
]}

Aschner, Michael ^{[1
,3
]}

机构：

[1] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

[2] Univ Zaragoza, Dept Psicol & Sociol, Campus Ciudad Escolar, Teruel 44003, Spain

[3] Sechenov First Moscow State Med Univ, Lab Mol Dietet, Moscow 119435, Russia

[4] Yaroslavl State Univ, Lab Ecobiomonitoring & Qual Control, Yaroslavl 150003, Russia

[5] IM Sechenov First Moscow State Med Univ Sechenov, World Class Res Ctr Digital Biodesign & Personali, Moscow 119435, Russia

[6] KG Razumovsky Moscow State Univ Technol & Managem, Dept Bioelementol, Moscow 109004, Russia

来源：

BIOMOLECULES | 2021年 / 11卷 / 12期

关键词：

genetic; alcohol; metals; cocaine; pesticides; QUANTITATIVE TRAIT LOCI; SYSTEMS GENETICS ANALYSIS; GULF-WAR ILLNESS; IRON-DEFICIENCY; MOUSE STRAINS; DOPAMINE TRANSPORTERS; LOCOMOTOR SENSITIVITY; INTRAVENOUS COCAINE; VENTRAL MIDBRAIN; SEX-DIFFERENCES;

D O I：

10.3390/biom11121762

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

BXD recombinant inbred (RI) lines represent a genetic reference population derived from a cross between C57BL/6J mice (B6) and DBA/2J mice (D2), which through meiotic recombination events possesses recombinant chromosomes containing B6 or D2 haplotype segments. The quantitative trait loci (QTLs) are the locations of segregating genetic polymorphisms and are fundamental to understanding genetic diversity in human disease susceptibility and severity. QTL mapping represents the typical approach for identifying naturally occurring polymorphisms that influence complex phenotypes. In this process, genotypic values at markers of known genomic locations are associated with phenotypic values measured in a segregating population. Indeed, BXD RI strains provide a powerful tool to study neurotoxicity induced by different substances. In this review, we describe the use of BXD RI lines to understand the underlying mechanisms of neurotoxicity in response to ethanol and cocaine, as well as metals and pesticide exposures.

引用

页数：12

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