Palytoxins and cytoskeleton: An overview

被引：23

作者：

Carmen Louzao, M. ^{[1
]}

Ares, Isabel R. ^{[1
]}

Cagide, Eva ^{[1
]}

Espina, Begona ^{[1
]}

Vilarino, Natalia ^{[1
]}

Alfonso, Amparo ^{[1
]}

Vieytes, Mercedes R. ^{[2
]}

Botana, Luis M. ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Dept Farmacol, Fac Vet, Lugo 27002, Spain

[2] Univ Santiago de Compostela, Dept Fisiol, Fac Vet, Lugo 27002, Spain

来源：

TOXICON | 2011年 / 57卷 / 03期

关键词：

Actin; Cytoskeleton; Microtubules; Ostreocin-D; Palytoxin; Ovatoxin-a; NA/K PUMP-CHANNELS; ACTIN CYTOSKELETON; OSTREOCIN-D; F-ACTIN; MOLECULAR-MECHANISMS; BINDING PROTEINS; OKADAIC ACID; CELLS; MEMBRANE; CALCIUM;

D O I：

10.1016/j.toxicon.2010.09.017

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cytoskeleton is a dynamic structure essential for a wide variety of normal cellular processes, including the maintenance of cell shape and morphology, volume regulation, membrane dynamics and signal transduction. Cytoskeleton is organized into microtubules, actin meshwork and intermediate filaments. Actin has been identified as a major target for destruction during apoptosis and is also important under pathological conditions such as cancers. Several natural compounds actively modulate actin organization by specific signaling cascades being useful tools to study cytoskeleton dynamics. Palytoxin is a large bioactive compound, first isolated from zoanthids, with a complex structure and different analogs such as ostreocin-D or ovatoxin-a. This toxin has been identified as a potent tumor promoter and cytotoxic molecule, which leads to actin filament distortion and triggers cell death or apoptosis. In this review we report the findings on the involvement of palytoxin and analogues modulating the actin cytoskeleton within different cellular models. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：460 / 469

页数：10

共 74 条

[11] Microtubule targeting agents: from biophysics to proteomics [J].

Calligaris, D. ;

Verdier-Pinard, P. ;

Devred, F. ;

Villard, C. ;

Braguer, D. ;

Lafitte, Daniel .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2010, 67 (07) :1089-1104

[12] The cytoskeleton, a structure that is susceptible to the toxic mechanism activated by palytoxins in human excitable cells [J].

Carmen Louzao, M. ;

Ares, Isabel R. ;

Vieytes, Mercedes R. ;

Valverde, Iago ;

Vieites, Juan M. ;

Yasumoto, Takeshi ;

Botana, Luis M. .

FEBS JOURNAL, 2007, 274 (08) :1991-2004

[13] Cytotoxic effect of palytoxin on mussel [J].

Carmen Louzao, M. ;

Espina, Begona ;

Cagide, Eva ;

Ares, Isabel R. ;

Alfonso, Amparo ;

Vieytes, Mercedes R. ;

Botana, Luis M. .

TOXICON, 2010, 56 (05) :842-847

[14] Marine toxins and the cytoskeleton: a new view of palytoxin toxicity [J].

Carmen Louzao, M. ;

Ares, Isabel R. ;

Cagide, Eva .

FEBS JOURNAL, 2008, 275 (24) :6067-6074

[15] Extracellular signal regulated kinase 5 mediates signals triggered by the novel tumor promoter palytoxin [J].

Charlson, Aaron T. ;

Zeliadt, Nicholette A. ;

Wattenberg, Elizabeth V. .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2009, 241 (02) :143-153

[16] Putative palytoxin and its new analogue, ovatoxin-a, in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak [J].

Ciminiello, Patrizia ;

Dell'Aversano, Carmela ;

Fattorusso, Ernesto ;

Forino, Martino ;

Tartaglione, Luciana ;

Grillo, Claudio ;

Melchiorre, Nunzia .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2008, 19 (01) :111-120

[17] Stereostructure and Biological Activity of 42-Hydroxy-palytoxin: A New Palytoxin Analogue from Hawaiian Palythoa Subspecies [J].

Ciminiello, Patrizia ;

Dell'Aversano, Carmela ;

Dello Iacovo, Emma ;

Fattorusso, Ernesto ;

Forino, Martino ;

Grauso, Laura ;

Tartaglione, Luciana ;

Florio, Chiara ;

Lorenzon, Paola ;

De Bortoli, Marco ;

Tubaro, Aurelia ;

Poli, Mark ;

Bignami, Gary .

CHEMICAL RESEARCH IN TOXICOLOGY, 2009, 22 (11) :1851-1859

[18]

Contreras RG, 1999, J CELL SCI, V112, P4223

[19] Bar domain proteins: a role in tubulation, scission and actin assembly in clathrin-mediated endocytosis [J].

Dawson, John C. ;

Legg, John A. ;

Machesky, Laura M. .

TRENDS IN CELL BIOLOGY, 2006, 16 (10) :493-498

[20] Human risk associated with palytoxin exposure [J].

Deeds, Jonathan R. ;

Schwartz, Michael D. .

TOXICON, 2010, 56 (02) :150-162

← 1 2 3 4 5 6 7 8 →