Palytoxins and cytoskeleton: An overview

被引：23

作者：

Carmen Louzao, M. ^{[1
]}

Ares, Isabel R. ^{[1
]}

Cagide, Eva ^{[1
]}

Espina, Begona ^{[1
]}

Vilarino, Natalia ^{[1
]}

Alfonso, Amparo ^{[1
]}

Vieytes, Mercedes R. ^{[2
]}

Botana, Luis M. ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Dept Farmacol, Fac Vet, Lugo 27002, Spain

[2] Univ Santiago de Compostela, Dept Fisiol, Fac Vet, Lugo 27002, Spain

来源：

TOXICON | 2011年 / 57卷 / 03期

关键词：

Actin; Cytoskeleton; Microtubules; Ostreocin-D; Palytoxin; Ovatoxin-a; NA/K PUMP-CHANNELS; ACTIN CYTOSKELETON; OSTREOCIN-D; F-ACTIN; MOLECULAR-MECHANISMS; BINDING PROTEINS; OKADAIC ACID; CELLS; MEMBRANE; CALCIUM;

D O I：

10.1016/j.toxicon.2010.09.017

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cytoskeleton is a dynamic structure essential for a wide variety of normal cellular processes, including the maintenance of cell shape and morphology, volume regulation, membrane dynamics and signal transduction. Cytoskeleton is organized into microtubules, actin meshwork and intermediate filaments. Actin has been identified as a major target for destruction during apoptosis and is also important under pathological conditions such as cancers. Several natural compounds actively modulate actin organization by specific signaling cascades being useful tools to study cytoskeleton dynamics. Palytoxin is a large bioactive compound, first isolated from zoanthids, with a complex structure and different analogs such as ostreocin-D or ovatoxin-a. This toxin has been identified as a potent tumor promoter and cytotoxic molecule, which leads to actin filament distortion and triggers cell death or apoptosis. In this review we report the findings on the involvement of palytoxin and analogues modulating the actin cytoskeleton within different cellular models. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：460 / 469

页数：10

共 74 条

[1]

Alberti C, 2009, EUR REV MED PHARMACO, V13, P13

[2] Actin-targeting natural products: structures, properties and mechanisms of action [J].

Allingham, J. S. ;

Klenchin, V. A. ;

Rayment, I. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2006, 63 (18) :2119-2134

[3] Actin cytoskeleton of rabbit intestinal cells is a target for potent marine phycotoxins [J].

Ares, IR ;

Louzao, MC ;

Vieytes, AR ;

Yasumoto, T ;

Botana, LA .

JOURNAL OF EXPERIMENTAL BIOLOGY, 2005, 208 (22) :4345-4354

[4] Lactone ring of pectenotoxins:: a key factor for their activity on cytoskeletal dynamics [J].

Ares, Isabel R. ;

Louzao, M. Carmen ;

Espina, Begona ;

Vieytes, Mercedes R. ;

Miles, Christopher O. ;

Yasumoto, Takeshi ;

Botana, Luis M. .

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2007, 19 (5-6) :283-292

[5] Ostreocin-D Impact on Globular Actin of Intact Cells [J].

Ares, Isabel R. ;

Cagide, Eva ;

Louzao, M. Carmen ;

Espina, Begona ;

Vieytes, Mercedes R. ;

Yasumoto, Takeshi ;

Botana, Luis M. .

CHEMICAL RESEARCH IN TOXICOLOGY, 2009, 22 (02) :374-381

[6] Large diameter of palytoxin-induced Na/K pump channels and modulation of palytoxin interaction by Na/K pump ligands [J].

Artigas, P ;

Gadsby, DC .

JOURNAL OF GENERAL PHYSIOLOGY, 2004, 123 (04) :357-376

[7]

Baartscheer Antonius, 2008, Cardiovascular & Hematological Agents in Medicinal Chemistry, V6, P229, DOI 10.2174/187152508785909546

[8] EFFECTS OF PALYTOXIN OR OUABAIN ON GROWTH AND SQUAMOUS DIFFERENTIATION OF HUMAN BRONCHIAL EPITHELIAL-CELLS INVITRO [J].

BONNARD, C ;

LECHNER, JF ;

GERWIN, BI ;

FUJIKI, H ;

HARRIS, CC .

CARCINOGENESIS, 1988, 9 (12) :2245-2249

[9] In and out of the cation pumps: P-Type ATPase structure revisited [J].

Bublitz, Maike ;

Poulsen, Hanne ;

Morth, J. Preben ;

Nissen, Poul .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2010, 20 (04) :431-439

[10] Production of Functionally Active Palytoxin-like Compounds by Mediterranean Ostreopsis cf. siamensis [J].

Cagide, Eva ;

Louzao, M. Carmen ;

Espina, Begona ;

Vieytes, Mercedes R. ;

Jaen, David ;

Maman, Luz ;

Yasumoto, Takeshi ;

Botana, Luis M. .

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2009, 23 (4-6) :431-440

← 1 2 3 4 5 6 7 8 →