INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants

被引：36

作者：

Andrade, Viviane M. ^{[1
]}

Christensen-Quick, Aaron ^{[1
]}

Agnes, Joseph ^{[1
]}

Tur, Jared ^{[1
]}

Reed, Charles ^{[1
]}

Kalia, Richa ^{[1
]}

Marrero, Idania ^{[1
]}

Elwood, Dustin ^{[1
]}

Schultheis, Katherine ^{[1
]}

Purwar, Mansi ^{[2
]}

Reuschel, Emma ^{[2
]}

McMullan, Trevor ^{[1
]}

Pezzoli, Patrick ^{[1
]}

Kraynyak, Kim ^{[1
]}

Sylvester, Albert ^{[1
]}

Mammen, Mammen P. ^{[1
]}

Tebas, Pablo ^{[3
]}

Joseph Kim, J. ^{[1
]}

Weiner, David B. ^{[2
]}

Smith, Trevor R. F. ^{[1
]}

Ramos, Stephanie J. ^{[1
]}

Humeau, Laurent M. ^{[1
]}

Boyer, Jean D. ^{[1
]}

Broderick, Kate E. ^{[1
]}

机构：

[1] Inovio Pharmaceut, Plymouth Meeting, PA 19462 USA

[2] Wistar Inst Anat & Biol, Vaccine & Immunotherapy Ctr, 3601 Spruce St, Philadelphia, PA 19104 USA

[3] Hosp Univ Penn, 3400 Spruce St, Philadelphia, PA 19104 USA

来源：

NPJ VACCINES | 2021年 / 6卷 / 01期

关键词：

D O I：

10.1038/s41541-021-00384-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2 VOC in subjects immunized with the DNA vaccine, INO-4800. INO-4800 vaccination induced neutralizing antibodies against all variants tested, with reduced levels detected against B.1.351. IFN gamma T cell responses were fully maintained against all variants tested.

引用

页数：4

共 27 条

[1] T cell-mediated immune response to respiratory coronaviruses [J].

Channappanavar, Rudragouda ;

Zhao, Jincun ;

Perlman, Stanley S. .

IMMUNOLOGIC RESEARCH, 2014, 59 (1-3) :118-128

[2]

Chen R. E., NAT MED, DOI [10.1038/s41591-021-01294-w(2021), DOI 10.1038/S41591-021-01294-W(2021)]

[3]

Davies NG, 2021, NATURE, V593, P270, DOI [10.1038/s41586-021-03426-1, 10.1101/2021.02.01.21250959]

[4] Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England [J].

Davies, Nicholas G. ;

Abbott, Sam ;

Barnard, Rosanna C. ;

Jarvis, Christopher, I ;

Kucharski, Adam J. ;

Munday, James D. ;

Pearson, Carl A. B. ;

Russell, Timothy W. ;

Tully, Damien C. ;

Washburne, Alex D. ;

Wenseleers, Tom ;

Gimma, Amy ;

Waites, William ;

Wong, Kerry L. M. ;

van Zandvoort, Kevin ;

Silverman, Justin D. ;

Diaz-Ordaz, Karla ;

Keogh, Ruth ;

Eggo, Rosalind M. ;

Funk, Sebastian ;

Jit, Mark ;

Atkins, Katherine E. ;

Edmunds, W. John .

SCIENCE, 2021, 372 (6538) :149-+

[5]

Dejnirattisai W., 2021, CELL, DOI [DOI 10.1016/J.CELL.2021.03.055(2021, 10.1016/j.cell.2021.03.055, DOI 10.1016/J.CELL.2021.03.055, 10.1016/j.cell.2021.03.055(2021]

[6]

Edara Venkata Viswanadh, 2021, bioRxiv, DOI 10.1101/2021.02.20.432046

[7] Intramuscular and Intradermal Electroporation of HIV-1 PENNVAX-GP(R) DNA Vaccine and IL-12 Is Safe, Tolerable, Acceptable in Healthy Adults [J].

Edupuganti, Srilatha ;

C. De Rosa, Stephen ;

Elizaga, Marnie ;

Lu, Yiwen ;

Han, Xue ;

Huang, Yunda ;

Swann, Edith ;

Polakowski, Laura ;

A. Kalams, Spyros ;

Keefer, Michael ;

Maenza, Janine ;

C. Wise, Megan ;

Yan, Jian ;

Morrow, Matthew P. ;

Khan, Amir S. ;

Boyer, Jean D. ;

Humeau, Laurent ;

White, Scott ;

Sardesai, Niranjan Y. ;

Bagarazzi, Mark L. ;

Gilbert, Peter B. ;

Kublin, James G. ;

Corey, Lawrence ;

Weiner, David B. .

VACCINES, 2020, 8 (04) :1-15

[8] Intrafamilial Exposure to SARS-CoV-2 Associated with Cellular Immune Response without Seroconversion, France [J].

Gallais, Floriane ;

Velay, Aurelie ;

Nazon, Charlotte ;

Wendling, Marie-Josee ;

Partisani, Marialuisa ;

Sibilia, Jean ;

Candon, Sophie ;

Fafi-Kremer, Samira .

EMERGING INFECTIOUS DISEASES, 2021, 27 (01) :113-121

[9]

Garcia-Beltran WF, 2021, CELL, V184, P2372, DOI [10.1016/j.cell.2021.03.013, 10.1101/2021.02.14.21251704, 10.1016/j.cell.2021.04.006]

[10]

Johnson, 2021, JOHNSON JOHNSON ANNO

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