Bone marrow stromal stem cells: Nature, biology, and potential applications

被引：1477

作者：

Bianco, P

Riminucci, M

Gronthos, S

Robey, PG

机构：

[1] Univ Roma La Sapienza, Dipartimento Med Sperimentale & Patol, I-00161 Rome, Italy

[2] Univ Aquila, Dipartimento Med Sperimentale, I-67100 Laquila, Italy

[3] Natl Inst Dent & Craniofacial Res, Craniofacial & Skeletal Dis Branch, NIH, Bethesda, MD USA

来源：

STEM CELLS | 2001年 / 19卷 / 03期

关键词：

marrow stromal stem cells; microvasculature; pericytes; transplantation; skeleton; stem cells; plasticity; gene therapy; somatic cell therapy;

D O I：

10.1634/stemcells.19-3-180

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Bone marrow stromal cells are progenitors of skeletal tissue components such as bone, cartilage, the hematopoiesis-supporting stroma, and adipocytes, In addition, they may be experimentally induced to undergo unorthodox differentiation, possibly forming neural and myogenic cells. As such, they represent an important paradigm of post-natal nonhematopoietic stem cells, and an easy source for potential therapeutic use, Along with an overview of the basics of their biology, we discuss here their potential nature as components of the vascular wall, and the prospects for their use in local and systemic transplantation and gene therapy.

引用

页码：180 / 192

页数：13

共 109 条

[1] RECIPIENT ORIGIN OF BONE MARROW-DERIVED FIBROBLASTIC STROMAL CELLS DURING ALL PERIODS FOLLOWING BONE-MARROW TRANSPLANTATION IN HUMANS [J].