Potentiality of microemulsion systems in treatment of ophthalmic disorders: Keratoconus and dry eye syndrome - In vivo study

被引：23
作者：
Lidich, Nina [1 ]
Garti-Levy, Sharon [2 ]
Aserin, Abraham [1 ]
Garti, Nissim [1 ]
机构：
[1] Hebrew Univ Jerusalem, Inst Chem, Casali Ctr Appl Chem, Edmond J Safra Campus, IL-9190401 Jerusalem, Israel
[2] Hebrew Univ Jerusalem, Lyotrop Delivery Syst, Edmond J Safra Campus, IL-9190401 Jerusalem, Israel
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2019年 / 173卷
关键词：
Microemulsions; Riboflavin; Omega fatty acids; Solubilization; Drug delivery system; Transepithelial permeation; Keratoconus; Dry eye syndrome; Collagen cross-linking; POLYUNSATURATED FATTY-ACIDS; COLLAGEN CROSS-LINKING; DRUG-DELIVERY SYSTEMS; RIBOFLAVIN; OPTIMIZATION; FORMULATION; EMULSIONS; EFFICACY; VITRO;
D O I：
10.1016/j.colsurfb.2018.09.063
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Microemulsions are widely studied as potential ocular drug delivery vehicles. In the present study we show the versatility of possible use microemulsions as ocular delivery vehicle. The ME is loaded with a hydrophilic drug, riboflavin phosphate (RFP) and a lipophilic, docosahexaenoic acid in triglyceride form (TG-DHA), each separately. These drugs treat keratoconus and dry eye syndrome, respectively. The advantage of using ME loaded with RFP is in overcoming eye epithelium debridement during collagen cross-linking therapy for treatment of keratoconus. ME loaded with lipophilic TG-DHA provides convenient dosage in liquid aqueous form of administration of highly lipophilic TG-DHA, which is known as a protective molecule in dry eye syndrome. The capability of RFP-loaded MEs was demonstrated in terms of improvement of biomechanical strength of the rabbit cornea, as a result of successful penetration of RFP through the intact epithelium. TG-DHA-loaded microemulsion applied topically onto an eye with induced dry eye syndrome showed the significant relief of the dry eye condition.
引用
收藏
页码：226 / 232
页数：7
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