Long-term outcomes after hematopoietic SCT for adult T-cell leukemia/lymphoma: results of prospective trials

被引：52
|
作者：
Choi, I. [2 ]
Tanosaki, R. [3 ]
Uike, N. [2 ]
Utsunomiya, A. [4 ]
Tomonaga, M. [5 ]
Harada, M. [6 ]
Yamanaka, T.
Kannagi, M. [7 ]
Okamura, J. [1 ]
机构：
[1] Kyushu Natl Canc Ctr, Inst Clin Res, Minami Ku, Fukuoka 8111395, Japan
[2] Kyushu Natl Canc Ctr, Dept Hematol, Fukuoka 8111395, Japan
[3] Natl Canc Ctr, Stem Cell Transplantat Unit, Tokyo, Japan
[4] Imamura Bun In Hosp, Dept Hematol, Kagoshima, Japan
[5] Nagasaki Univ, Mol Med Unit, Dept Hematol, Atom Bomb Dis Inst,Sch Med, Nagasaki 852, Japan
[6] Kyushu Univ, Grad Sch Med Sci, Fukuoka 812, Japan
[7] Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Tokyo, Japan
来源：
BONE MARROW TRANSPLANTATION | 2011年 / 46卷 / 01期
基金：
日本学术振兴会;
关键词：
adult T-cell leukemia/lymphoma; allogeneic hematopoietic SCT; reduced-intensity conditioning regimen; HTLV-1 proviral load; RETROSPECTIVE ANALYSIS; LEUKEMIA-LYMPHOMA; TRANSPLANTATION; INTENSITY; IMPACT;
D O I：
10.1038/bmt.2010.92
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
We have previously conducted clinical trials of allogeneic hematopoietic SCT with reduced-intensity conditioning regimen (RIC) for adult T-cell leukemia/lymphoma (ATLL)-a disease caused by human T-lymphotropic virus type 1 (HTLV-1) infection and having a dismal prognosis. Long-term follow-up studies of these trials revealed that 10 of the 29 patients have survived for a median of 82 months (range, 54-100 months) after RIC, indicating a possible curability of the disease by RIC. However, we have also observed that the patterns of post-RIC changes in HTLV-1 proviral load over time among the 10 survivors were classified into three patterns. This is the first report to clarify the long-term outcomes after RIC for ATLL patients. Bone Marrow Transplantation (2011) 46, 116-118; doi:10.1038/bmt.2010.92; published online 19 April 2010
引用
收藏
页码：116 / 118
页数：3
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