Tumor necrosis factor alpha plays a role in the acceleration of atherosclerosis by Chlamydia pneumoniae in mice

被引：20
作者：
Campbell, LA [1 ]
Nosaka, T [1 ]
Rosenfeld, ME [1 ]
Yaraei, K [1 ]
Kuo, CC [1 ]
机构：
[1] Univ Washington, Dept Pathobiol, Seattle, WA 98195 USA
来源：
INFECTION AND IMMUNITY | 2005年 / 73卷 / 05期
关键词：
D O I：
10.1128/IAI.73.5.3164-3165.2005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The role of tumor necrosis factor alpha (TNF-alpha) in Chlamydia pneumoniae atherogenesis was evaluated in TNF-alpha p55 receptor-deficient C57BL/6J mice fed a high-fat/high-cholesterol diet. No acceleration of atherosclerotic lesion development was observed in infected mice compared to uninfected mice, indicating that TNF-alpha plays a role in the acceleration of atherosclerosis by C. pneumoniae.
引用
收藏
页码：3164 / 3165
页数：2
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