Tex13a Optimizes Sperm Motility via Its Potential Roles in mRNA Turnover

被引：4

作者：

Li, Yinchuan ^{[1
]}

Mi, Panpan ^{[1
]}

Chen, Xue ^{[1
]}

Wu, Jiabao ^{[2
]}

Liu, Xiaohua ^{[2
]}

Tang, Yunge ^{[2
]}

Cheng, Jinmei ^{[1
]}

Huang, Yingying ^{[1
]}

Qin, Weibing ^{[2
]}

Cheng, C. Yan ^{[3
]}

Sun, Fei ^{[1
]}

机构：

[1] Nantong Univ, Inst Reprod Med, Med Sch, Nantong, Peoples R China

[2] Guangdong Prov Fertil Hosp, Guangdong Prov Reprod Sci Inst, NHC Key Lab Male Reprod & Genet, Guangzhou, Peoples R China

[3] Populat Council, Ctr Biomed Res, Mary M Wohlibrd Lab Male Contracept Res, 1230 York Ave, New York, NY 10021 USA

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷

基金：

中国国家自然科学基金;

关键词：

Tex13a; CCR4-NOT; Cnot1; spermiogenesis; sperm motility; knock-out; CCR4-NOT COMPLEX; CHROMATOID BODY; GENE-EXPRESSION; MECHANISMS; DECAY; DEADENYLATION; TRANSLATION; PATTERNS;

D O I：

10.3389/fcell.2021.761627

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

mRNAs have been found to undergo substantial selective degradation during the late stages of spermiogenesis. However, the mechanisms regulating this biological process are unknown. In this report, we have identified Tex13a, a spermatid-specific gene that interacts with the CCR4-NOT complex and is implicated in the targeted degradation of mRNAs encoding particular structural components of sperm. Deletion of Tex13a led to a delayed decay of these mRNAs, lowered the levels of house-keeping genes, and ultimately lowered several key parameters associated with the control of sperm motility, such as the path velocity (VAP, average path velocity), track speed (VCL, velocity curvilinear), and rapid progression.

引用

页数：9

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