Characterization of viral double-stranded RNA-binding proteins

被引:13
作者
Jacobs, BL [1 ]
Langland, JO
Brandt, T
机构
[1] Arizona State Univ, Dept Microbiol, Tempe, AZ 85287 USA
[2] Arizona State Univ, Grad Program Mol & Cellular Biol, Tempe, AZ 85287 USA
来源
METHODS-A COMPANION TO METHODS IN ENZYMOLOGY | 1998年 / 15卷 / 03期
关键词
D O I
10.1006/meth.1998.0626
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Several viruses have been shown to code for proteins that specifically bind to double-stranded RNA or RNA with large amounts of secondary structure. These proteins have been implicated in providing interferon resistance to viruses and in inhibiting induction of apoptosis by viruses, and have been suggested to be involved in regulation of viral and cellular protein synthesis in infected cells. This article describes methods for detecting and analyzing viral double-stranded RNA binding proteins. (C) 1998 Academic Press.
引用
收藏
页码:225 / 232
页数:8
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