Flexible organic frameworks sequester neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo

被引：7

作者：

Wu, Yan ^{[1
]}

Liu, Yue-Yang ^{[1
]}

Liu, Hong-Kun ^{[1
]}

Yu, Shang-Bo ^{[2
]}

Lin, Furong ^{[2
]}

Zhou, Wei ^{[1
]}

Wang, Hui ^{[1
]}

Zhang, Dan-Wei ^{[1
]}

Li, Zhan-Ting ^{[1
]}

Ma, Da ^{[3
,4
]}

机构：

[1] Fudan Univ, Shanghai Key Lab Mol Catalysis & Innovat Mat, Dept Chem, Shanghai 200438, Peoples R China

[2] Chinese Acad Sci, Key Lab Synthet & Self Assembly Chem Organ Funct, Shanghai Inst Organ Chem SIOC, 345 Lingling Lu, Shanghai 200032, Peoples R China

[3] Taizhou Univ, Sch Pharmaceut & Mat Engn, 1139 Shifu Ave, Jiaojiang 318000, Zhejiang, Peoples R China

[4] Taizhou Univ, Inst Adv Studies, 1139 Shifu Ave, Jiaojiang 318000, Zhejiang, Peoples R China

来源：

CHEMICAL SCIENCE | 2022年 / 13卷 / 32期

基金：

中国国家自然科学基金;

关键词：

PHOTODYNAMIC THERAPY; DNA; SUGAMMADEX; DELIVERY; HOSTS;

D O I：

10.1039/d2sc02456j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Supramolecular sequestration and reversal of neuromuscular block (NMB) have great clinical applications. Water-soluble flexible organic frameworks (FOFs) cross-linked by disulfide bonds are designed and prepared. Different linker lengths are introduced to FOFs to give them varied pore sizes. FOFs are anionic nanoscale polymers and capable of encapsulating cationic neuromuscular blocking agents (NMBAs), including rocuronium (Roc), vecuronium (Vec), pancuronium (Panc) and cisatracurium (Cis). A host-guest study confirms that FOFs bind NMBAs in water. The multivalency interaction between FOFs and NMBAs is able to sequester NMBAs, and prevent them from escaping. These FOFs are non-toxic and biocompatible. Animal studies show that FOFs are effective for the reversal of NMB induced by Roc, Vec and Cis, which shorten the time to a train-of-four ratio of 0.9 by 2.6, 3.8 and 5.7-fold compared to a placebo, respectively.

引用

页码：9243 / 9248

页数：6

共 40 条

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