Recent progresses in exosome-based systems for targeted drug delivery to the brain

被引：84
作者：
Bashyal, Santosh [1 ,2 ]
Thapa, Chhitij [1 ]
Lee, Sangkil [1 ,3 ]
机构：
[1] Keimyung Univ, Coll Pharm, Daegu 42601, South Korea
[2] Univ Texas Austin, Coll Pharm, Div Mol Pharmaceut & Drug Delivery, Austin, TX 78712 USA
[3] Keimyung Univ, Coll Pharm, 1095 Dalgubeol Daero, Daegu 42601, South Korea
来源：
JOURNAL OF CONTROLLED RELEASE | 2022年 / 348卷
基金：
新加坡国家研究基金会;
关键词：
Brain drug delivery systems; Exosomes; Brain diseases; Neurodegenerative diseases; Brain cancers; CEREBROSPINAL FLUID BARRIER; ATOMIC-FORCE MICROSCOPY; EXTRACELLULAR VESICLES; PARKINSONS-DISEASE; NERVOUS-SYSTEM; CANCER-THERAPY; STROMAL CELLS; IN-VITRO; RNA; BIOGENESIS;
D O I：
10.1016/j.jconrel.2022.06.011
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Despite the multiple ongoing and novel initiatives for developing brain-targeted drug delivery systems, insurmountable obstacles remain. A perfect drug delivery device that can bypass the brain-blood barrier and boost therapeutic efficacy is urgently needed for clinical applications. Exosomes hold unrivaled benefits as a drug delivery vehicle for treating brain diseases due to their endogenous and innate attributes. Unique properties, such as the ability to penetrate physical barriers, biocompatibility, innate targeting features, ability to leverage natural intracellular trafficking pathways, favored tumor homing, and stability, make exosomes suitable for brain-targeted drug delivery. Herein, we provide an overview of recent exosome-based drug delivery nanoplatforms and discuss how these inherent vesicles can be used to deliver therapeutic agents to the brain to cure neurodegenerative diseases, brain tumors, and other brain disorders. Moreover, we review the current roadblocks associated with exosomes and other brain-targeted drug delivery systems and discuss future directions for achieving successful therapy outcomes.
引用
收藏
页码：723 / 744
页数：22
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