The Distance Between Donor and Acceptor Affects the Proportion of C1′ and C2′ Oxidation Products of DNA in a BrU-Containing Excess Electron Transfer System

被引：19

作者：

Tashiro, Ryu ^{[2
]}

Ohtsuki, Akimichi ^{[1
]}

Sugiyama, Hiroshi ^{[1
,3
]}

机构：

[1] Kyoto Univ, Dept Chem, Grad Sch Sci, Sakyo Ku, Kyoto 6068502, Japan

[2] Suzuka Univ Med Sci, Fac Pharmaceut Sci, Suzuka, Mie 5138670, Japan

[3] Kyoto Univ, Inst Integrated Cell Mat Sci iCeMS, Sakyo Ku, Kyoto 6068502, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 41期

关键词：

HYDROGEN ABSTRACTION; CHARGE-TRANSFER; DUPLEX DNA; OLIGONUCLEOTIDES; PHOTOREACTION; TRANSPORT; SEQUENCE; PHOTOIRRADIATION; GENERATION; RADICALS;

D O I：

10.1021/ja106184w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have investigated the products of U-Br in excess electron transfer and have demonstrated that in DNA the proportion of products changes with the distance between the donor and acceptor. On the basis of a labeling experiment using (H2O)-O-18, we have shown that hole migration from Pr center dot+ formed after charge separation is involved in the reaction.

引用

页码：14361 / 14363

页数：3

共 30 条

[1]

Behrens C., 2002, Angewandte Chemie, V114, P1841

[2] Models of DNA C1′ radicals.: Structural, spectral, and chemical properties of the thyminylmethyl radical and the 2′-deoxyuridin-1′-yl radical [J].